Mahmoud Rafieian-Kopaei1, Abolfazl Khoshdel2, Soleiman Kheiri3, Rabin Shemian4. 1. Professor, Medical Plants Research Center, Shahrekord University of Medical Sciences , Shahrekord, Iran . 2. Associate Professor, Department of Pediatrics, Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences , Shahrekord, Iran . 3. Associate Professor, Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences , Shahrekord, Iran . 4. Medical Doctor, Shahrekord University of Medical Sciences , Shahrekord, Iran .
Abstract
INTRODUCTION: Consumption of cotoneaster may reduce neonatal jaundice. AIM: Hence this study was undertaken to determine the effect of mothers' cotoneaster consumption on treatment of their neonates' jaundice. MATERIALS AND METHODS: In this randomized clinical trial study, 120 neonates with jaundice referred to a hospital in southwest Iran were enrolled by nonprobability sampling and divided randomly into four groups. In the first group both mothers and neonates received cotoneaster; in the second group only mothers; in the third group only neonates; and in the fourth group the neonates received distilled water as placebo. Phototherapy was done under the same condition for all neonates. RESULTS: The reduction of bilirubin was significantly higher in treatment groups compared to control group (p<0.05). Bilirubin in the group of neonates whose mothers consumed cotoneaster was less compared to control group at 24 and 36 hours (p<0.05) and the highest reduction in bilirubin was observed in the first group. The mean duration of hospitalization was longer for the control group (p<0.05). CONCLUSION: Consumption of cotoneaster by both mothers and neonates caused a decrease in neonatal jaundice more rapidly compared to other groups and decreased the duration of hospitalization. Cotoneaster consumption by mothers, neonates, or both may be useful in treatment of neonatal jaundice.
RCT Entities:
INTRODUCTION: Consumption of cotoneaster may reduce neonatal jaundice. AIM: Hence this study was undertaken to determine the effect of mothers' cotoneaster consumption on treatment of their neonates' jaundice. MATERIALS AND METHODS: In this randomized clinical trial study, 120 neonates with jaundice referred to a hospital in southwest Iran were enrolled by nonprobability sampling and divided randomly into four groups. In the first group both mothers and neonates received cotoneaster; in the second group only mothers; in the third group only neonates; and in the fourth group the neonates received distilled water as placebo. Phototherapy was done under the same condition for all neonates. RESULTS: The reduction of bilirubin was significantly higher in treatment groups compared to control group (p<0.05). Bilirubin in the group of neonates whose mothers consumed cotoneaster was less compared to control group at 24 and 36 hours (p<0.05) and the highest reduction in bilirubin was observed in the first group. The mean duration of hospitalization was longer for the control group (p<0.05). CONCLUSION: Consumption of cotoneaster by both mothers and neonates caused a decrease in neonatal jaundice more rapidly compared to other groups and decreased the duration of hospitalization. Cotoneaster consumption by mothers, neonates, or both may be useful in treatment of neonatal jaundice.