Anju Barhai Teli1, Rumi Deori2, Sidhartha Protim Saikia3, Kalyani Pathak4, Rita Panyang5, Rashmi Rajkakati1. 1. Associate Professor, Department of Biochemistry, Assam Medical College & Hospital , Dibrugarh, Assam, India . 2. Assistant Professor, Department of Biochemistry, Assam Medical College & Hospital , Dibrugarh, Assam, India . 3. Senior Research Fellow, Department of Anatomy, Assam Medical College & Hospital , Dibrugarh, Assam, India . 4. Junior Research Fellow, Department of Biochemistry, Assam Medical College & Hospital , Dibrugarh, Assam, India . 5. Assistant Professor, Department of Paediatrics, Assam Medical College & Hospital , Dibrugarh, Assam, India .
Abstract
INTRODUCTION: β-Thalassaemias are common genetic disorders in the Indian subcontinent and its status has not been well studied in the Upper Assam region of North Eastern India. AIM: The aim of the study was to show the prevalence of β- thalassaemias and its co-existence with Haemoglobin E and Haemoglobin S in the Upper Assam region of North Eastern India. MATERIALS AND METHODS: A total of 1200 anaemic patients were investigated for β- thalassaemias. Complete Blood Count (CBC) and High Performance Liquid Chromatography (HPLC) were done for screening. RESULTS: Out of 1200 patients screened, 5.83% β-thalassaemia trait, 2.33% compound Hb E/β-Thalassaemia, 1.33% β-thalassaemia major and 0.42% compound Hb S/β- thalassaemia were detected. A high incidence of thalassaemia is found among the people of Upper Assam region of North Eastern India. CONCLUSION: The only way to prevent the disease is carrier detection and awareness among the people about it.
INTRODUCTION: β-Thalassaemias are common genetic disorders in the Indian subcontinent and its status has not been well studied in the Upper Assam region of North Eastern India. AIM: The aim of the study was to show the prevalence of β- thalassaemias and its co-existence with Haemoglobin E and Haemoglobin S in the Upper Assam region of North Eastern India. MATERIALS AND METHODS: A total of 1200 anaemic patients were investigated for β- thalassaemias. Complete Blood Count (CBC) and High Performance Liquid Chromatography (HPLC) were done for screening. RESULTS: Out of 1200 patients screened, 5.83% β-thalassaemia trait, 2.33% compound Hb E/β-Thalassaemia, 1.33% β-thalassaemia major and 0.42% compound Hb S/β- thalassaemia were detected. A high incidence of thalassaemia is found among the people of Upper Assam region of North Eastern India. CONCLUSION: The only way to prevent the disease is carrier detection and awareness among the people about it.
Authors: Hari Shankar; Mrigendra Pal Singh; Syed Shah Areeb Hussain; Sobhan Phookan; Kuldeep Singh; Neelima Mishra Journal: Front Public Health Date: 2022-07-28