Sumitra Govindarajan1, Kishore Vellingiri2. 1. Assistant Professor, Department of Biochemistry, PSG IMSR , Coimbatore, India . 2. Student, PSG IMSR , Coimbatore, India .
Abstract
INTRODUCTION: Dietary supplements provide a novel population based health approach for treating hyperlipidemias. Red yeast rice is known to have lipid lowering effects. Combination of red yeast rice with various oils is taken by different population around the world. AIM: In this present work, we aimed to compare the effects of red yeast rice with different oil (coconut, rice bran and sunflower oil) supplementations on lipid levels and oxidative stress in rats fed on hypercholesterolemic diet. MATERIALS AND METHODS: A Randomized controlled study was conducted on 28 male Sprague Dawley rats. It included 4 arms-Control arm (hypercholesterolemic diet), Test arm A (hypercholesterolemic diet +Red yeast rice + Rice bran oil), arm B (hypercholesterolemic diet +Red yeast rice + Coconut oil) and arm C (hypercholesterolemic diet +Red yeast rice + Sunflower oil). At the end of one month, serum cholesterol, triglycerides, MDA and paraoxonase was measured. The mean values of analytes between the different groups were compared using student 't-' test. RESULTS: The rats fed with red yeast rice and rice bran oil combination showed significantly lower levels of serum cholesterol, triglycerides and MDA when compared to the controls. The serum paraoxonase levels were significantly higher in this group when compared to the controls. The rats fed with red yeast rice and coconut oil combination showed significantly lower serum cholesterol and MDA levels when compared to the controls. The mean triglyceride and paraoxonase levels did not show any statistically significant difference from the controls. The rats on red yeast rice and sunflower oil combination did not show any statistically significant difference in the lipid levels and oxidative stress parameters. CONCLUSION: The food combination which had best outcome in preventing the development of hyperlipidemia and oxidative stress in rats fed with hypercholesterolemic diet was red yeast rice and rice bran oil. Combining red yeast rice with coconut oil and sunflower oil gave suboptimal benefits.
INTRODUCTION: Dietary supplements provide a novel population based health approach for treating hyperlipidemias. Red yeastrice is known to have lipid lowering effects. Combination of red yeastrice with various oils is taken by different population around the world. AIM: In this present work, we aimed to compare the effects of red yeastrice with different oil (coconut, rice bran and sunfloweroil) supplementations on lipid levels and oxidative stress in rats fed on hypercholesterolemic diet. MATERIALS AND METHODS: A Randomized controlled study was conducted on 28 male Sprague Dawley rats. It included 4 arms-Control arm (hypercholesterolemic diet), Test arm A (hypercholesterolemic diet +Red yeastrice + Rice bran oil), arm B (hypercholesterolemic diet +Red yeastrice + Coconut oil) and arm C (hypercholesterolemic diet +Red yeastrice + Sunfloweroil). At the end of one month, serum cholesterol, triglycerides, MDA and paraoxonase was measured. The mean values of analytes between the different groups were compared using student 't-' test. RESULTS: The rats fed with red yeastrice and rice bran oil combination showed significantly lower levels of serum cholesterol, triglycerides and MDA when compared to the controls. The serum paraoxonase levels were significantly higher in this group when compared to the controls. The rats fed with red yeastrice and coconut oil combination showed significantly lower serum cholesterol and MDA levels when compared to the controls. The mean triglyceride and paraoxonase levels did not show any statistically significant difference from the controls. The rats on red yeastrice and sunfloweroil combination did not show any statistically significant difference in the lipid levels and oxidative stress parameters. CONCLUSION: The food combination which had best outcome in preventing the development of hyperlipidemia and oxidative stress in rats fed with hypercholesterolemic diet was red yeastrice and rice bran oil. Combining red yeastrice with coconut oil and sunfloweroil gave suboptimal benefits.
Authors: Ng Shy Kai; Tee Ai Nee; Elaine Lai Chia Ling; Tan Chin Ping; Long Kamariah; Nyam Kar Lin Journal: Asian Pac J Trop Med Date: 2015-01 Impact factor: 1.226
Authors: Veronique Verhoeven; Anastasia Van der Auwera; Luc Van Gaal; Roy Remmen; Sandra Apers; Michel Stalpaert; Johan Wens; Nina Hermans Journal: BMC Complement Altern Med Date: 2015-03-10 Impact factor: 3.659
Authors: Veronique Verhoeven; Maja Lopez Hartmann; Roy Remmen; Johan Wens; Sandra Apers; Paul Van Royen Journal: BMC Complement Altern Med Date: 2013-07-18 Impact factor: 3.659