| Literature DB >> 27190191 |
Uma Krishna1, Judith Romero-Gallo1, Giovanni Suarez1, Ayeetin Azah2, Andrzej M Krezel3, Matthew G Varga4, Mark H Forsyth5, Richard M Peek6.
Abstract
Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.Entities:
Keywords: H. pylori; acid resistance; hypochlorhydia
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Year: 2016 PMID： 27190191 PMCID： PMC4957439 DOI： 10.1093/infdis/jiw189
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226