Literature DB >> 27190147

Twitching motility and cAMP levels: signal transduction through a single methyl-accepting chemotaxis protein.

Vibhuti H Jansari1, Vishwakanth Y Potharla1, Geoff T Riddell1, Sonia L Bardy2.   

Abstract

The Pseudomonas aeruginosa Chp chemosensory system regulates twitching motility, intracellular adenosine 3('') 5(')-cyclic monophosphate (cAMP) levels and is postulated to be involved in directional twitching towards phosphatidylethanolamine (PE). Because PilJ is the only methyl-accepting chemotaxis protein (MCP) identified in the Chp system, we determined the role of PilJ in mediating signal transduction for the distinct outputs of this system. Mutants that lack the periplasmic domain of PilJ (pilJΔ74-273) showed lower levels of cAMP but retained directional twitching towards PE. While initial studies revealed reduced twitching motility by PilJΔ74-273, this was due to decreased cAMP levels. Our data illustrate the importance of the periplasmic domain of PilJ in regulating cAMP. This is the first time a defined domain within PilJ has been identified as having a distinct role in signal transduction. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  PilJ; Pseudomonas aeruginosa; cAMP; chemotaxis; signal transduction; twitching motility

Mesh：

Substances：

Year:  2016        PMID： 27190147      PMCID： PMC5975279          DOI： 10.1093/femsle/fnw119

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  27 in total

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Authors:  S L Mowbray; M O Sandgren
Journal:  J Struct Biol       Date:  1998-12-15       Impact factor: 2.867

2.  The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity.

Authors:  Nanette B Fulcher; Phillip M Holliday; Erich Klem; Martin J Cann; Matthew C Wolfgang
Journal:  Mol Microbiol       Date:  2010-03-16       Impact factor: 3.501

Review 3.  Bacterial chemoreceptors: high-performance signaling in networked arrays.

Authors:  Gerald L Hazelbauer; Joseph J Falke; John S Parkinson
Journal:  Trends Biochem Sci       Date:  2007-12-31       Impact factor: 13.807

4.  Pseudomonas aeruginosa exhibits directed twitching motility up phosphatidylethanolamine gradients.

Authors:  D B Kearns; J Robinson; L J Shimkets
Journal:  J Bacteriol       Date:  2001-01       Impact factor: 3.490

Review 5.  Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa.

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Journal:  Nature       Date:  2000-08-31       Impact factor: 49.962

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8.  Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.

Authors:  Cynthia B Whitchurch; Andrew J Leech; Michael D Young; Derek Kennedy; Jennifer L Sargent; Jacob J Bertrand; Annalese B T Semmler; Albert S Mellick; Paul R Martin; Richard A Alm; Matthew Hobbs; Scott A Beatson; Bixing Huang; Lam Nguyen; James C Commolli; Joanne N Engel; Aldis Darzins; John S Mattick
Journal:  Mol Microbiol       Date:  2004-05       Impact factor: 3.501

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Authors:  Mingshan Li; Gerald L Hazelbauer
Journal:  J Bacteriol       Date:  2004-06       Impact factor: 3.490

10.  The Pseudomonas aeruginosa pilK gene encodes a chemotactic methyltransferase (CheR) homologue that is translationally regulated.

Authors:  A Darzins
Journal:  Mol Microbiol       Date:  1995-02       Impact factor: 3.501
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2.  Cyclic AMP-Independent Control of Twitching Motility in Pseudomonas aeruginosa.

Authors:  Ryan N C Buensuceso; Martin Daniel-Ivad; Sara L N Kilmury; Tiffany L Leighton; Hanjeong Harvey; P Lynne Howell; Lori L Burrows
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4.  The Molecular Mechanism of Nitrate Chemotaxis via Direct Ligand Binding to the PilJ Domain of McpN.

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Review 6.  Two-component systems required for virulence in Pseudomonas aeruginosa.

Authors:  Vanessa I Francis; Emma C Stevenson; Steven L Porter
Journal:  FEMS Microbiol Lett       Date:  2017-06-15       Impact factor: 2.742
  6 in total

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