Literature DB >> 27189599

Non-Demented Individuals with Alzheimer's Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies.

Olga Zolochevska1, Giulio Taglialatela.   

Abstract

Alzheimer's disease (AD) is a terminal neurodegenerative disorder that is characterized by accumulation of amyloid plaques and neurofibrillary tangles in the central nervous system. However, certain individuals remain cognitively intact despite manifestation of substantial plaques and tangles consistent with what would be normally associated with fully symptomatic AD. Mechanisms that allow these subjects to escape dementia remain unresolved and understanding such protective biological processes could reveal novel targets for the development of effective treatments for AD. In this review article we discuss potential compensatory mechanisms that allow these individuals to remain cognitively intact despite the typical AD neuropathology.

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Year:  2016        PMID： 27189599      PMCID： PMC6007878          DOI： 10.2174/1381612822666160518142110

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  91 in total

1.  Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study.

Authors:  Michael Gold; Claire Alderton; Marina Zvartau-Hind; Sally Egginton; Ann M Saunders; Michael Irizarry; Suzanne Craft; Gary Landreth; Ulla Linnamägi; Sharon Sawchak
Journal:  Dement Geriatr Cogn Disord       Date:  2010-08-21       Impact factor: 2.959

Review 2.  Synaptic integration and plasticity of new neurons in the adult hippocampus.

Authors:  Shaoyu Ge; Kurt A Sailor; Guo-li Ming; Hongjun Song
Journal:  J Physiol       Date:  2008-05-22       Impact factor: 5.182

3.  Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease.

Authors:  Stephen W Scheff; Douglas A Price; Mubeen A Ansari; Kelly N Roberts; Frederick A Schmitt; Milos D Ikonomovic; Elliott J Mufson
Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472

Review 4.  Oxidative stress and Alzheimer's disease.

Authors:  B H Choi
Journal:  Neurobiol Aging       Date:  1995 Jul-Aug       Impact factor: 4.673

5.  Amyloid deposition is associated with impaired default network function in older persons without dementia.

Authors:  Reisa A Sperling; Peter S Laviolette; Kelly O'Keefe; Jacqueline O'Brien; Dorene M Rentz; Maija Pihlajamaki; Gad Marshall; Bradley T Hyman; Dennis J Selkoe; Trey Hedden; Randy L Buckner; J Alex Becker; Keith A Johnson
Journal:  Neuron       Date:  2009-07-30       Impact factor: 17.173

6.  Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease.

Authors:  P V Arriagada; K Marzloff; B T Hyman
Journal:  Neurology       Date:  1992-09       Impact factor: 9.910

7.  Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques.

Authors:  R Katzman; R Terry; R DeTeresa; T Brown; P Davies; P Fuld; X Renbing; A Peck
Journal:  Ann Neurol       Date:  1988-02       Impact factor: 10.422

8.  A multi-center randomized proof-of-concept clinical trial applying [¹⁸F]FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer's disease.

Authors:  Sofia Tzimopoulou; Vincent J Cunningham; Thomas E Nichols; Graham Searle; Nick P Bird; Prafull Mistry; Ian J Dixon; William A Hallett; Brandon Whitcher; Andrew P Brown; Marina Zvartau-Hind; Narinder Lotay; Robert Y K Lai; Mary Castiglia; Barbara Jeter; Julian C Matthews; Kewei Chen; Dan Bandy; Eric M Reiman; Michael Gold; Eugenii A Rabiner; Paul M Matthews
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

9.  Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer's disease.

Authors:  Aderbal R T Silva; Lea T Grinberg; Jose M Farfel; Breno S Diniz; Leandro A Lima; Paulo J S Silva; Renata E L Ferretti; Rafael M Rocha; Wilson Jacob Filho; Dirce M Carraro; Helena Brentani
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

Review 10.  Mitochondrial dysfunction: different routes to Alzheimer's disease therapy.

Authors:  Pasquale Picone; Domenico Nuzzo; Luca Caruana; Valeria Scafidi; Marta Di Carlo
Journal:  Oxid Med Cell Longev       Date:  2014-08-20       Impact factor: 6.543
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  19 in total

1.  The Role of Race in Relations of Social Support to Hippocampal Volumes Among Older Adults.

Authors:  Desirée C Bygrave; Constance S Gerassimakis; Denée T Mwendwa; Guray Erus; Christos Davatzikos; Regina S Wright
Journal:  Res Aging       Date:  2021-05-12

2.  Soluble Amyloid-beta Aggregates from Human Alzheimer's Disease Brains.

Authors:  Thomas J Esparza; Norelle C Wildburger; Hao Jiang; Mihika Gangolli; Nigel J Cairns; Randall J Bateman; David L Brody
Journal:  Sci Rep       Date:  2016-12-05       Impact factor: 4.379

3.  Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system.

Authors:  YoungSoo Kim; Yong Kyoung Yoo; Hye Yun Kim; Jee Hoon Roh; Jinsik Kim; Seungyeop Baek; Jinny Claire Lee; Hye Jin Kim; Myung-Sic Chae; Dahye Jeong; Dongsung Park; Sejin Lee; HoChung Jang; Kyeonghwan Kim; Jeong Hoon Lee; Byung Hyun Byun; Su Yeon Park; Jeong Ho Ha; Kyo Chul Lee; Won Woo Cho; Jae-Seung Kim; Jae-Young Koh; Sang Moo Lim; Kyo Seon Hwang
Journal:  Sci Adv       Date:  2019-04-17       Impact factor: 14.136

4.  Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes.

Authors:  Maria-Adelaide Micci; Balaji Krishnan; Elizabeth Bishop; Wen-Ru Zhang; Jutatip Guptarak; Auston Grant; Olga Zolochevska; Batbayar Tumurbaatar; Whitney Franklin; Claudia Marino; Steven G Widen; Arjun Luthra; Steven G Kernie; Giulio Taglialatela
Journal:  Mol Neurodegener       Date:  2019-06-14       Impact factor: 14.195

Review 5.  α-synuclein in the pathophysiology of Alzheimer's disease.

Authors:  Daniel Twohig; Henrietta M Nielsen
Journal:  Mol Neurodegener       Date:  2019-06-11       Impact factor: 14.195

6.  Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.

Authors:  Jing Zhang; Baian Chen; Jing Lu; Yi Wu; Shubo Wang; Zitong Yao; Liming Zhu; Yanhua Qiao; Quan Sun; Wei Qin; Qiao Zhao; Jianping Jia; Cuibai Wei
Journal:  Aging Cell       Date:  2019-06-04       Impact factor: 9.304

7.  Case report and literature review of Huntington disease with intermediate CAG expansion.

Authors:  Stefan D Jevtic; John P Provias
Journal:  BMJ Neurol Open       Date:  2020-02-09

Review 8.  Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology.

Authors:  Frédérique K Kok; Suzanne L van Leerdam; Elizabeth C M de Lange
Journal:  J Alzheimers Dis       Date:  2022       Impact factor: 4.160

9.  Postsynaptic Proteome of Non-Demented Individuals with Alzheimer's Disease Neuropathology.

Authors:  Olga Zolochevska; Nicole Bjorklund; Randall Woltjer; John E Wiktorowicz; Giulio Taglialatela
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

10.  Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer's disease mouse model promotes synaptic resilience.

Authors:  Krystyn Z Bourne; Chandramouli Natarajan; Carlos X Medina Perez; Batbayar Tumurbaatar; Giulio Taglialatela; Balaji Krishnan
Journal:  Sci Rep       Date:  2019-12-04       Impact factor: 4.379
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