| Literature DB >> 27188987 |
A Parri1,2, Montserrat Fitó3,4,5, C F Torres6, D Muñoz-Aguayo7, H Schröder7,8, J F Cano1, L Vázquez6, G Reglero6,9, María-Isabel Covas10,11,12.
Abstract
Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled, crossover study, 26 non-diabetes obese individuals were assigned two preparations with low (LAC, 10 mg AKGs) and high (HAC, 20 mg AKGs) AKG content. Intervention periods were of 3 weeks preceded by 2-week washout periods in which shark liver oil was avoided. Cholesterol, C3, C4, and vascular endothelial growth factor (VEGF) decreased in a linear trend (P < 0.01) from baseline (control) to LAC and HAC. Values after HAC were significantly lower (P < 0.05) versus both baseline and after LAC. No adverse effects were observed or reported. Data from this pilot study open a promising field for the study of the beneficial effects of AKGs on cardiovascular risk factors in obese individuals.Entities:
Keywords: Alkylglycerols; Complement 3; Complement 4; Inflammation; Obesity; Vascular endothelial growth factor
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Year: 2016 PMID： 27188987 DOI： 10.1007/s10787-016-0265-4
Source DB: PubMed Journal: Inflammopharmacology ISSN： 0925-4692 Impact factor: 4.473