Akio Hiwatashi1, Osamu Togao1, Koji Yamashita1, Kazufumi Kikuchi1, Makoto Obara2, Takashi Yoshiura1,3, Hiroshi Honda1. 1. 1 Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2. 2 MR Clinical Science, Philips Electronics Japan, Tokyo, Japan. 3. 3 Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Abstract
OBJECTIVE: Diffusivity of pituitary adenoma has not been investigated fully. The purpose of this study was to evaluate the feasibility of turbo field echo with diffusion-sensitized driven-equilibrium (DSDE-TFE) preparation for pituitary adenoma in the sella turcica and unaffected anterior lobe of the pituitary gland. METHODS: This retrospective study included 23 adult patients with pituitary adenomas. Among them, 6 each were prolactin-producing adenomas and growth hormone-producing adenomas (GH) and the remaining 11 were non-functioning adenomas (NON). The apparent diffusion coefficients (ADCs) were measured in the pituitary adenoma and in the unaffected pituitary gland using coronal reformatted plane. RESULTS: All pituitary adenomas were clearly visualized on DSDE-TFE and ADC maps without obvious geometrical distortion. There were no statistically significant differences in ADC of the all pituitary adenoma (1.50 ± 0.61 × 10(-3) mm(2) s(-1)) and the unaffected anterior lobe of the pituitary gland (1.49 ± 0.37 × 10(-3) mm(2) s(-1), p = 0.99). The ADC in prolactin-producing adenomas (2.04 ± 0.76 × 10(-3) mm(2) s(-1)) was significantly higher than that in GH (1.26 ± 0.47 × 10(-3) mm(2) s(-1); p < 0.05) and NON (1.33 ± 0.42 × 10(-3) mm(2) s(-1); p = 0.04). There was no statistically significant difference between GH and NON (p = 0.97). The intraclass correlation coefficient for ADC was 0.985 in adenomas and 0.635 in unaffected glands. CONCLUSION: With its insensitivity to field inhomogeneity and high spatial resolution, DSDE-TFE proved a feasible method for evaluating the diffusivity in the pituitary gland and adenoma. ADVANCES IN KNOWLEDGE: DSDE-TFE could enable us to assess ADC of pituitary adenoma in the sella turcica with high resolution and few susceptibility artefacts.
OBJECTIVE: Diffusivity of pituitary adenoma has not been investigated fully. The purpose of this study was to evaluate the feasibility of turbo field echo with diffusion-sensitized driven-equilibrium (DSDE-TFE) preparation for pituitary adenoma in the sella turcica and unaffected anterior lobe of the pituitary gland. METHODS: This retrospective study included 23 adult patients with pituitary adenomas. Among them, 6 each were prolactin-producing adenomas and growth hormone-producing adenomas (GH) and the remaining 11 were non-functioning adenomas (NON). The apparent diffusion coefficients (ADCs) were measured in the pituitary adenoma and in the unaffected pituitary gland using coronal reformatted plane. RESULTS: All pituitary adenomas were clearly visualized on DSDE-TFE and ADC maps without obvious geometrical distortion. There were no statistically significant differences in ADC of the all pituitary adenoma (1.50 ± 0.61 × 10(-3) mm(2) s(-1)) and the unaffected anterior lobe of the pituitary gland (1.49 ± 0.37 × 10(-3) mm(2) s(-1), p = 0.99). The ADC in prolactin-producing adenomas (2.04 ± 0.76 × 10(-3) mm(2) s(-1)) was significantly higher than that in GH (1.26 ± 0.47 × 10(-3) mm(2) s(-1); p < 0.05) and NON (1.33 ± 0.42 × 10(-3) mm(2) s(-1); p = 0.04). There was no statistically significant difference between GH and NON (p = 0.97). The intraclass correlation coefficient for ADC was 0.985 in adenomas and 0.635 in unaffected glands. CONCLUSION: With its insensitivity to field inhomogeneity and high spatial resolution, DSDE-TFE proved a feasible method for evaluating the diffusivity in the pituitary gland and adenoma. ADVANCES IN KNOWLEDGE: DSDE-TFE could enable us to assess ADC of pituitary adenoma in the sella turcica with high resolution and few susceptibility artefacts.
Authors: Jerrold L Boxerman; Jeffrey M Rogg; John E Donahue; Jason T Machan; Marc A Goldman; Curt E Doberstein Journal: AJR Am J Roentgenol Date: 2010-09 Impact factor: 3.959
Authors: E Nagao; T Yoshiura; A Hiwatashi; M Obara; K Yamashita; H Kamano; Y Takayama; K Kobayashi; H Honda Journal: AJNR Am J Neuroradiol Date: 2011-02-03 Impact factor: 3.825
Authors: Xinyuan Miao; Yuankui Wu; Dapeng Liu; Hangyi Jiang; David Woods; Moshe T Stern; Nicholas I S Blair; Raag D Airan; Chetan Bettegowda; Keri S Rosch; Qin Qin; Peter C M van Zijl; Jay J Pillai; Jun Hua Journal: Radiology Date: 2019-11-12 Impact factor: 11.105