Literature DB >> 27186318

Neuroprotective effect of lidocaine: is there clinical potential?

Tiandong Leng1, Xiuren Gao2, James P Dilger3, Jun Lin3.   

Abstract

Local anesthetic lidocaine has been shown to be protective in animal models of focal and global ischemia as well as in in vitro hypoxic models. Lidocaine has been tested in patients for its potential protective effect on postoperative cognitive dysfunction. This mini-review summarizes the laboratory and clinical evidences and discusses its clinical applications as neuroprotective agent.

Entities:  

Keywords:  Lidocaine; neuroprotection; postoperative cognitive dysfunction; stroke

Year:  2016        PMID： 27186318      PMCID： PMC4859874     

Source DB:  PubMed          Journal:  Int J Physiol Pathophysiol Pharmacol        ISSN： 1944-8171


  40 in total

1.  The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgery.

Authors:  Dongxin Wang; Xinmin Wu; Jun Li; Feng Xiao; Xiaoying Liu; Meijin Meng
Journal:  Anesth Analg       Date:  2002-11       Impact factor: 5.108

2.  Neuroprotective effect of low-dose lidocaine in a rat model of transient focal cerebral ischemia.

Authors:  B Lei; J E Cottrell; I S Kass
Journal:  Anesthesiology       Date:  2001-08       Impact factor: 7.892

3.  Effects of delayed administration of low-dose lidocaine on transient focal cerebral ischemia in rats.

Authors:  Baiping Lei; Susanna Popp; Christine Capuano-Waters; James E Cottrell; Ira S Kass
Journal:  Anesthesiology       Date:  2002-12       Impact factor: 7.892

4.  Cerebral protection by lidocaine during cardiac operations.

Authors:  S J Mitchell; O Pellett; D F Gorman
Journal:  Ann Thorac Surg       Date:  1999-04       Impact factor: 4.330

5.  Delayed treatment with lidocaine reduces mouse microglial cell injury and cytokine production after stimulation with lipopolysaccharide and interferon γ.

Authors:  Hae-Jeong Jeong; Daowei Lin; Liaoliao Li; Zhiyi Zuo
Journal:  Anesth Analg       Date:  2012-01-16       Impact factor: 5.108

6.  Effects of lignocaine on pressor response to laryngoscopy and endotracheal intubation during general anaesthesia in rigid suspension laryngoscopy.

Authors:  I S Kocamanoglu; S Cengel Kurnaz; A Tur
Journal:  J Laryngol Otol       Date:  2014-12-15       Impact factor: 1.469

7.  Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats.

Authors:  B Lei; S Popp; C Capuano-Waters; J E Cottrell; I S Kass
Journal:  Neuroscience       Date:  2004       Impact factor: 3.590

8.  Continuous lidocaine infusion and focal feline cerebral ischemia.

Authors:  M T Shokunbi; A W Gelb; X M Wu; D J Miller
Journal:  Stroke       Date:  1990-01       Impact factor: 7.914

Review 9.  Adverse neurologic events: risks of intracardiac versus extracardiac surgery.

Authors:  N A Nussmeier
Journal:  J Cardiothorac Vasc Anesth       Date:  1996-01       Impact factor: 2.628

10.  Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.

Authors:  Joseph P Mathew; G Burkhard Mackensen; Barbara Phillips-Bute; Hilary P Grocott; Donald D Glower; Daniel T Laskowitz; James A Blumenthal; Mark F Newman
Journal:  Stroke       Date:  2009-01-22       Impact factor: 7.914
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  2 in total

1.  Short-Term Visual Experience Leads to Potentiation of Spontaneous Activity in Mouse Superior Colliculus.

Authors:  Qingpeng Yu; Hang Fu; Gang Wang; Jiayi Zhang; Biao Yan
Journal:  Neurosci Bull       Date:  2021-01-04       Impact factor: 5.203

2.  Anesthetic Preconditioning as Endogenous Neuroprotection in Glaucoma.

Authors:  Tsung-Han Chou; Ganeswara Rao Musada; Giovanni Luca Romano; Elizabeth Bolton; Vittorio Porciatti
Journal:  Int J Mol Sci       Date:  2018-01-13       Impact factor: 5.923
  2 in total

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