Literature DB >> 27186286

Houttuynia cordata Thunb reverses oxaliplatin-induced neuropathic pain in rat by regulating Th17/Treg balance.

Cheng-Fu Wan1, Li-Li Zheng2, Yan Liu1, Xue Yu1.   

Abstract

Oxaliplatin is a widely used anti-advanced colorectal cancer drug, while it could induce neuropathy. Houttuynia cordata Thunb (HCT) has a wide range of biological activities, such as anti-inflammation, anti-cancer, and immune regulation. In the present study, we investigated the effect of HCT on oxaliplatin-induced neuropathy in rat models. HCT (1000 mg/kg/day) significantly decreased the number of withdrawal responses and the withdrawal latency in oxaliplatin-treated rats. HCT could down-regulated the serum levels of Interleukin-6 (IL-6) and macrophage inflammatory protein1-α (MIP-1α) in oxaliplatin-treated rats. Th17/Treg balance was reversed by HCT in oxaliplatin-treated rats by regulating PI3K/Akt/mTOR signaling pathway. The present results suggest that HCT is useful as a therapeutic drug for oxaliplatin-induced neuropathic pain.

Entities:  

Keywords:  Houttuynia cordata Thunb; Oxaliplatin; PI3K/Akt/mTOR; Th17/Treg; neuropathic pain

Year:  2016        PMID： 27186286      PMCID： PMC4859645     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  20 in total

Review 1.  Oxaliplatin: a review of approved uses.

Authors:  Alexander Stein; Dirk Arnold
Journal:  Expert Opin Pharmacother       Date:  2012-01       Impact factor: 3.889

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Journal:  Anticancer Res       Date:  2012-09       Impact factor: 2.480

Review 3.  Oxaliplatin-related side effects: characteristics and management.

Authors:  Jim Cassidy; Jean-Louis Misset
Journal:  Semin Oncol       Date:  2002-10       Impact factor: 4.929

4.  Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice.

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5.  PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.

Authors:  Yutaka Kurebayashi; Shigenori Nagai; Ai Ikejiri; Masashi Ohtani; Kenji Ichiyama; Yukiko Baba; Taketo Yamada; Shohei Egami; Takayuki Hoshii; Atsushi Hirao; Satoshi Matsuda; Shigeo Koyasu
Journal:  Cell Rep       Date:  2012-03-29       Impact factor: 9.423

6.  Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain.

Authors:  Dongxing Li; Younju Lee; Woojin Kim; Kyungjin Lee; Hyunsu Bae; Sun Kwang Kim
Journal:  Toxins (Basel)       Date:  2015-06-29       Impact factor: 4.546

7.  Antineuropathic profile of N-palmitoylethanolamine in a rat model of oxaliplatin-induced neurotoxicity.

Authors:  Lorenzo Di Cesare Mannelli; Alessandra Pacini; Francesca Corti; Serena Boccella; Livio Luongo; Emanuela Esposito; Salvatore Cuzzocrea; Sabatino Maione; Antonio Calignano; Carla Ghelardini
Journal:  PLoS One       Date:  2015-06-03       Impact factor: 3.240

8.  Anti-inflammatory T-cell shift in neuropathic pain.

Authors:  Benjamin Luchting; Banafscheh Rachinger-Adam; Jens Heyn; Ludwig Christian Hinske; Simone Kreth; Shahnaz Christina Azad
Journal:  J Neuroinflammation       Date:  2015-01-21       Impact factor: 8.322

9.  Anti-inflammatory effect of Houttuynia cordata injection.

Authors:  H M Lu; Y Z Liang; L Z Yi; X J Wu
Journal:  J Ethnopharmacol       Date:  2005-10-05       Impact factor: 4.360

10.  Beneficial effect of TNF-α inhibition on diabetic peripheral neuropathy.

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Journal:  J Neuroinflammation       Date:  2013-06-04       Impact factor: 8.322
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  10 in total

1.  Houttuynia cordata Thunb rescues retinal ganglion cells through inhibiting microglia activation in a rat model of retinal ischemia-reperfusion.

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Journal:  Int J Ophthalmol       Date:  2020-12-18       Impact factor: 1.779

2.  Changes of Treg and Th17 cells as well as cytokines in children with acute bronchitis.

Authors:  Zhiqiang Tu; Haiyan Xue; Wei Chen; Lanfang Cao; Weiqi Zhang
Journal:  Exp Ther Med       Date:  2017-08-22       Impact factor: 2.447

3.  Probiotic Therapy (BIO-THREE) Mitigates Intestinal Microbial Imbalance and Intestinal Damage Caused by Oxaliplatin.

Authors:  Wenzhen Yuan; Xingpeng Xiao; Xuan Yu; Fuquan Xie; Pengya Feng; Kamran Malik; Jingyuan Wu; Ze Ye; Peng Zhang; Xiangkai Li
Journal:  Probiotics Antimicrob Proteins       Date:  2021-05-06       Impact factor: 4.609

4.  Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy.

Authors:  Yong-Da Liu; Zhi-Bin Wang; Guang Han; Li Jin; Ping Zhao
Journal:  J Pain Res       Date:  2019-01-23       Impact factor: 3.133

5.  Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway.

Authors:  Hao Fang; Zhen Yang; Liu Yang
Journal:  Neuroreport       Date:  2021-05-05       Impact factor: 1.703

6.  The Role of Vascular-Immune Interactions in Modulating Chemotherapy Induced Neuropathic Pain.

Authors:  Tameille Valentine; Lydia Hardowar; Jasmine Elphick-Ross; Richard P Hulse; Mark Paul-Clark
Journal:  Front Pharmacol       Date:  2022-06-22       Impact factor: 5.988

7.  Integrated therapeutic plasma exchange and traditional Chinese medicine treatment in a patient with severe COVID-19: A case report.

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Journal:  J Integr Med       Date:  2022-09-03

8.  The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain.

Authors:  Wei-Min Luo; Han Du; Hong-Liang Jiang; Ying-Jun Deng; Xue Liang; Ping Qiu; Yao Cheng
Journal:  Evid Based Complement Alternat Med       Date:  2022-09-06       Impact factor: 2.650

Review 9.  Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review.

Authors:  Khanchuila Shingnaisui; Tapan Dey; Prasenjit Manna; Jatin Kalita
Journal:  J Ethnopharmacol       Date:  2018-03-30       Impact factor: 4.360

Review 10.  Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy.

Authors:  Giulia Fumagalli; Laura Monza; Guido Cavaletti; Roberta Rigolio; Cristina Meregalli
Journal:  Front Immunol       Date:  2021-02-04       Impact factor: 7.561
  10 in total

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