| Literature DB >> 27185357 |
Evelien G G Sprenkeler1,2, Mark S Gresnigt1,2, Frank L van de Veerdonk1,2.
Abstract
LC3-associated phagocytosis (LAP) is a non-canonical autophagy pathway involved in the maturation of single-membrane phagosomes and subsequent killing of ingested pathogens by phagocytes. This pathway is initiated following recognition of pathogens by pattern recognition receptors and leads to the recruitment of LC3 into the phagosomal membrane. This form of phagocytosis is utilized for the antifungal host defence and is required for an efficient fungal killing. Here, we provide an overview of the LAP pathway and review the role of LAP in anti-Aspergillus host defence, as well as mechanisms induced by Aspergillus that modulate LAP to promote its survival in the host.Entities:
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Year: 2016 PMID： 27185357 DOI： 10.1111/cmi.12616
Source DB: PubMed Journal: Cell Microbiol ISSN： 1462-5814 Impact factor: 3.715