Literature DB >> 2718502

Phenytoin-carbamazepine cross-sensitivity.

S B Reents1, W E Luginbuhl, S M Davis.   

Abstract

A case of phenytoin-carbamazepine cross-sensitivity is presented. Similar signs and symptoms occurred during administration of both drugs. A common metabolic intermediate is offered as a possible explanation of the mechanism. Clinicians should be careful when choosing alternatives in patients with hypersensitivity reactions to anticonvulsants. Valproic acid may be the safest choice in this setting.

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Year:  1989        PMID： 2718502     DOI： 10.1177/106002808902300308

Source DB:  PubMed          Journal:  DICP        ISSN： 1042-9611


  4 in total

Review 1.  Anticonvulsant hypersensitivity syndrome: incidence, prevention and management.

Authors:  S R Knowles; L E Shapiro; N H Shear
Journal:  Drug Saf       Date:  1999-12       Impact factor: 5.606

2.  Cross Hypersensitivity Syndrome between Phenytoin and Carbamazepine.

Authors:  Nerea Moyano Sierra; Benito García; Javier Marco; Susana Plaza; Francisco Hidalgo; Teresa Bermejo
Journal:  Pharm World Sci       Date:  2005-06

3.  Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.

Authors:  M Pirmohamed; A Graham; P Roberts; D Smith; D Chadwick; A M Breckenridge; B K Park
Journal:  Br J Clin Pharmacol       Date:  1991-12       Impact factor: 4.335

Review 4.  Immunological adverse effects of anticonvulsants. What is their clinical relevance?

Authors:  F De Ponti; S Lecchini; M Cosentino; C M Castelletti; A Malesci; G M Frigo
Journal:  Drug Saf       Date:  1993-03       Impact factor: 5.606
  4 in total

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