Yan Wang1, Jin Zhang1, Yuesheng Qain1, Xiaofeng Tang1, Huawei Ling2, Kemin Chen2, Yan Li1, Pingjin Gao1, Dingliang Zhu3. 1. Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China. 2. Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 3. Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China. Electronic address: zhudingliang@sibs.ac.cn.
Abstract
BACKGROUND: Intracranial arterial stenosis is a common cause of ischemic stroke in Asians. We therefore sought to explore the relationship of brachial-ankle pulse wave velocity and intracranial arterial stenosis in 834 stroke-free hypertensive patients. METHODS: Intracranial arterial stenosis was evaluated through computerized tomographic angiography. Brachial-ankle pulse wave velocity was measured by an automated cuff device. RESULTS: The top decile of brachial-ankle pulse wave velocity was significantly associated with intracranial arterial stenosis (P = .027, odds ratio = 1.82; 95% confidence interval: 1.07-3.10). The patients with the top decile of brachial-ankle pulse wave velocity showed 56% higher risk for the presence of intracranial arterial stenosis to the whole population, which was more significant in patients younger than 65 years old. We also found that brachial-ankle pulse wave velocity related to both intracranial arterial stenosis and homocysteine. CONCLUSION: Our study showed the association of brachial-ankle pulse wave velocity with asymptomatic intracranial arterial stenosis in hypertension patients, especially in relative younger subjects. Brachial-ankle pulse wave velocity might be a relatively simple and repeatable measurement to detect hypertension patients in high risk of intracranial arterial stenosis.
BACKGROUND:Intracranial arterial stenosis is a common cause of ischemic stroke in Asians. We therefore sought to explore the relationship of brachial-ankle pulse wave velocity and intracranial arterial stenosis in 834 stroke-free hypertensivepatients. METHODS:Intracranial arterial stenosis was evaluated through computerized tomographic angiography. Brachial-ankle pulse wave velocity was measured by an automated cuff device. RESULTS: The top decile of brachial-ankle pulse wave velocity was significantly associated with intracranial arterial stenosis (P = .027, odds ratio = 1.82; 95% confidence interval: 1.07-3.10). The patients with the top decile of brachial-ankle pulse wave velocity showed 56% higher risk for the presence of intracranial arterial stenosis to the whole population, which was more significant in patients younger than 65 years old. We also found that brachial-ankle pulse wave velocity related to both intracranial arterial stenosis and homocysteine. CONCLUSION: Our study showed the association of brachial-ankle pulse wave velocity with asymptomatic intracranial arterial stenosis in hypertensionpatients, especially in relative younger subjects. Brachial-ankle pulse wave velocity might be a relatively simple and repeatable measurement to detect hypertensionpatients in high risk of intracranial arterial stenosis.