Giuseppe Lippi1, Ruggero Buonocore2, Alessandra Picanza2, Fabio Schirosa3, Gianfranco Cervellin3. 1. a Section of Clinical Biochemistry , University of Verona , Verona , Italy. 2. b Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma , Parma , Italy. 3. c Emergency Department, Academic Hospital of Parma , Parma , Italy.
Abstract
INTRODUCTION: Red blood cell distribution width (RDW) is significantly associated with a variety of human disorders. This study aimed to investigate whether RDW value at admission may predict the need of hospitalisation in patients presenting to the emergency department (ED) with acute allergic reactions. MATERIALS AND METHODS: The study population consisted of adult patients (aged > 17) admitted to the ED for acute allergic reactions. RESULTS: One hundred and thirty-two subjects were included, 12 of whom (9%) required hospital admission for severity of symptoms. Patients who needed hospital admission displayed significantly lower values of haemoglobin and significantly higher values of RDW-coefficient of variation (RDW-CV). In multivariate analysis, haemoglobin and RDW-CV were found to be independent predictors of hospital admission. The area under the curve (AUC), sensitivity and specificity for predicting hospital admission were 0.72, 0.88 and 0.42 for haemoglobin and 0.73, 0.88 and 0.50 for RDW-CV, respectively. The combination of these tests (both positive) was characterised by 0.76 AUC, 0.83 sensitivity, 0.67 specificity, 0.96 negative predictive value and 0.30 positive predictive. DISCUSSION: The results of this study suggest that two common and inexpensive parameters such as haemoglobin and RDW are independent predictors of hospital admission in patients presenting to the ED with acute allergic reactions.
INTRODUCTION: Red blood cell distribution width (RDW) is significantly associated with a variety of human disorders. This study aimed to investigate whether RDW value at admission may predict the need of hospitalisation in patients presenting to the emergency department (ED) with acute allergic reactions. MATERIALS AND METHODS: The study population consisted of adult patients (aged > 17) admitted to the ED for acute allergic reactions. RESULTS: One hundred and thirty-two subjects were included, 12 of whom (9%) required hospital admission for severity of symptoms. Patients who needed hospital admission displayed significantly lower values of haemoglobin and significantly higher values of RDW-coefficient of variation (RDW-CV). In multivariate analysis, haemoglobin and RDW-CV were found to be independent predictors of hospital admission. The area under the curve (AUC), sensitivity and specificity for predicting hospital admission were 0.72, 0.88 and 0.42 for haemoglobin and 0.73, 0.88 and 0.50 for RDW-CV, respectively. The combination of these tests (both positive) was characterised by 0.76 AUC, 0.83 sensitivity, 0.67 specificity, 0.96 negative predictive value and 0.30 positive predictive. DISCUSSION: The results of this study suggest that two common and inexpensive parameters such as haemoglobin and RDW are independent predictors of hospital admission in patients presenting to the ED with acute allergic reactions.
Authors: Gianni Turcato; Valentina Serafini; Alice Dilda; Chiara Bovo; Beatrice Caruso; Giorgio Ricci; Giuseppe Lippi Journal: Ann Transl Med Date: 2016-07
Authors: Gianni Turcato; Gianfranco Cervellin; Gian Luca Salvagno; Eleonora Zaccaria; Giuseppe Bartucci; Marco David; Antonio Bonora; Massimo Zannoni; Giorgio Ricci; Giuseppe Lippi Journal: J Med Biochem Date: 2017-01-25 Impact factor: 3.402