Literature DB >> 27181771

Activin receptor IIA ligand trap in chronic kidney disease: 1 drug to prevent 2 complications-or even more?

Ziad A Massy1, Tilman B Drueke2.   

Abstract

Vascular calcification and kidney fibrosis are 2 important features of chronic kidney disease. Bone morphogenetic proteins/growth differentiation factors and their receptors are implicated in the pathogenesis of both processes. Modulation of the bone morphogenetic protein/growth differentiation factor pathways by a soluble chimeric protein that contains the activin receptor IIA (ActRIIA) domain and acts as an ActRIIA ligand trap for activin and other ligands could become a new therapeutic strategy for vascular calcification and kidney fibrosis in chronic kidney disease.
Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27181771     DOI： 10.1016/j.kint.2016.02.006

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  3 in total

Review 1.  The systemic nature of CKD.

Authors:  Carmine Zoccali; Raymond Vanholder; Ziad A Massy; Alberto Ortiz; Pantelis Sarafidis; Friedo W Dekker; Danilo Fliser; Denis Fouque; Gunnar H Heine; Kitty J Jager; Mehmet Kanbay; Francesca Mallamaci; Gianfranco Parati; Patrick Rossignol; Andrzej Wiecek; Gerard London
Journal:  Nat Rev Nephrol       Date:  2017-04-24       Impact factor: 28.314

2.  The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients.

Authors:  Ade Yonata; Zulkhair Ali; Taufik Indrajaya; Erial Bahar; Ian Effendi; Novadian Suhaimi; Suprapti Suprapti
Journal:  Int J Nephrol       Date:  2020-11-09

3.  A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.

Authors:  Danielle Vaughan; Robert Mitchell; Oliver Kretz; David Chambers; Maciej Lalowski; Helge Amthor; Olli Ritvos; Arja Pasternack; Antonios Matsakas; Sakthivel Vaiyapuri; Tobias B Huber; Bernd Denecke; Abir Mukherjee; Darius Widera; Ketan Patel
Journal:  Dis Model Mech       Date:  2021-02-19       Impact factor: 5.758
  3 in total

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