Chad Swank1, Jyutika Mehta2, Christina Criminger3. 1. School of Physical Therapy, Texas Woman's University, 5500 Southwestern Medical Ave., Dallas, TX 75235, United States. Electronic address: cswank@twu.edu. 2. Department of Communication Science and Disorders, Texas Woman's University, 5500 Southwestern Medical Ave., Dallas, TX 75235,United States. Electronic address: jmehta@twu.edu. 3. School of Physical Therapy, Texas Woman's University, 5500 Southwestern Medical Ave., Dallas, TX 75235, United States. Electronic address: ccriminger@twu.edu.
Abstract
BACKGROUND: Parkinson's disease (PD) progressively impairs motor and cognitive function. Gait dysfunction in PD is exacerbated during dual task gait. Transcranial direct current stimulation (tDCS) may therapeutically benefit motor and cognitive deficits. We examined the effect of a bilateral tDCS protocol on dual task gait in people with PD. MATERIAL AND METHODS:Participants with PD between 50 and 80 years received two sessions of tDCS protocol (1 active, 1 sham) separated by 7days. tDCS protocols were randomized and blinded to participants. After each tDCS protocol, participants performed single and dual task gait. Single 20-min session of bilateral tDCS (dorsolateral prefrontal cortex; left=anode, right=cathode) at 2mA and one sham session. Each participant was assessed at baseline for disease severity [Unified Parkinson's Disease Rating Scale (UPDRS)] and executive function [Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)]. Following each tDCS condition (active and sham), participants performed Timed Up and Go (TUG) single and dual task conditions (TUGalone, TUGmotor, TUGcognitive) and PDQ-39. RESULTS:Ten participants average age of 68.7 years (±10.2) and average PD duration average 7.9 years (±7.1) were included. The UPDRS (M=37) and RBANS (M=13%ile) were administered prior to testing. No differences were observed on dependent t-test for TUG conditions or PDQ-39. Dual task cost TUGmotor was -20.95% (tDCSactive) versus -22.58% (tDCSsham) and TUGcognitive was -25.24% (tDCSactive) versus -41.85% (tDCSsham). CONCLUSIONS: Our bilateral tDCS protocol in people with PD did not significantly improve dual task gait. However, dual task cost following tDCS was lessened, most dramatically in the presence of a cognitive distractor. A larger sample size is warranted to draw further conclusions about our bilateral tDCS approach.
RCT Entities:
BACKGROUND:Parkinson's disease (PD) progressively impairs motor and cognitive function. Gait dysfunction in PD is exacerbated during dual task gait. Transcranial direct current stimulation (tDCS) may therapeutically benefit motor and cognitive deficits. We examined the effect of a bilateral tDCS protocol on dual task gait in people with PD. MATERIAL AND METHODS:Participants with PD between 50 and 80 years received two sessions of tDCS protocol (1 active, 1 sham) separated by 7days. tDCS protocols were randomized and blinded to participants. After each tDCS protocol, participants performed single and dual task gait. Single 20-min session of bilateral tDCS (dorsolateral prefrontal cortex; left=anode, right=cathode) at 2mA and one sham session. Each participant was assessed at baseline for disease severity [Unified Parkinson's Disease Rating Scale (UPDRS)] and executive function [Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)]. Following each tDCS condition (active and sham), participants performed Timed Up and Go (TUG) single and dual task conditions (TUGalone, TUGmotor, TUGcognitive) and PDQ-39. RESULTS: Ten participants average age of 68.7 years (±10.2) and average PD duration average 7.9 years (±7.1) were included. The UPDRS (M=37) and RBANS (M=13%ile) were administered prior to testing. No differences were observed on dependent t-test for TUG conditions or PDQ-39. Dual task cost TUGmotor was -20.95% (tDCSactive) versus -22.58% (tDCSsham) and TUGcognitive was -25.24% (tDCSactive) versus -41.85% (tDCSsham). CONCLUSIONS: Our bilateral tDCS protocol in people with PD did not significantly improve dual task gait. However, dual task cost following tDCS was lessened, most dramatically in the presence of a cognitive distractor. A larger sample size is warranted to draw further conclusions about our bilateral tDCS approach.
Authors: Gilles Allali; Helena M Blumen; Hervé Devanne; Elvira Pirondini; Arnaud Delval; Dimitri Van De Ville Journal: Neurophysiol Clin Date: 2018-10-25 Impact factor: 3.734
Authors: Rubén Hernández de Paz; Diego Serrano-Muñoz; Soraya Pérez-Nombela; Elisabeth Bravo-Esteban; Juan Avendaño-Coy; Julio Gómez-Soriano Journal: J Neuroeng Rehabil Date: 2019-09-14 Impact factor: 4.262