Literature DB >> 27181490

Can a Silver-Coated Arthrodesis Implant Provide a Viable Alternative to Above Knee Amputation in the Unsalvageable, Infected Total Knee Arthroplasty?

Chris P Wilding1, George A Cooper1, Alexandra K Freeman1, Michael C Parry1, Lee Jeys1.   

Abstract

BACKGROUND: In the unsalvageable, infected total knee arthroplasty, knee arthrodesis is one treatment option with lower reported reinfection rates compared with repeated 2-stage revision and improved function compared with amputation. One possible method for reducing incidence of recurrent infection treated by arthrodesis is the use of a silver-coated implant. We report our experience of silver-coated arthrodesis nails used for managing infected revision arthroplasty. We primarily assess the rate of reinfection and rate of amputation and report functional outcome measures.
METHODS: Retrospective analysis of all patients undergoing knee arthrodesis with a silver-coated arthrodesis nail between 2008 and 2014. Patient-reported data were recorded prearthrodesis and postarthrodesis (Oxford Knee Score and Short Form-36) as well as evidence of recurrent of infection, subsequent surgery, and the necessity for amputation.
RESULTS: Eight patients underwent arthrodesis using the silver-coated arthrodesis nail. Mean duration of follow-up was 16 months (5-35 months). At the point of follow-up, there were no amputations, deaths, or implant revisions. One case of recurrent infection was successfully treated with washout and debridement. The mean prearthrodesis and postarthrodesis Oxford Knee Score difference was +8.9 points (P = .086) with significantly improved pain (P = .019), night pain (P = .021), and ease of standing (P = .003).
CONCLUSION: Arthrodesis of the knee using a silver-coated intramedullary device is successful in eradicating infection and allowing limb conservation. Where infection does recur, this can be successfully treated with implant retention. The use of a silver-coated arthrodesis nail should be considered as an alternative to amputation for patients with a multiply revised and infected total knee arthroplasty.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  arthrodesis; coating; infection; knee; silver

Mesh:

Substances:

Year:  2016        PMID: 27181490     DOI: 10.1016/j.arth.2016.04.009

Source DB:  PubMed          Journal:  J Arthroplasty        ISSN: 0883-5403            Impact factor:   4.757


  9 in total

Review 1.  Silver-coated megaprostheses: review of the literature.

Authors:  Tom Schmidt-Braekling; Arne Streitbuerger; Georg Gosheger; Friedrich Boettner; Markus Nottrott; Helmut Ahrens; Ralf Dieckmann; Wiebke Guder; Dimosthenis Andreou; Gregor Hauschild; Burkhard Moellenbeck; Wenzel Waldstein; Jendrik Hardes
Journal:  Eur J Orthop Surg Traumatol       Date:  2017-03-06

Review 2.  Silver-coated megaprosthesis in prevention and treatment of peri-prosthetic infections: a systematic review and meta-analysis about efficacy and toxicity in primary and revision surgery.

Authors:  Michele Fiore; Andrea Sambri; Riccardo Zucchini; Claudio Giannini; Davide Maria Donati; Massimiliano De Paolis
Journal:  Eur J Orthop Surg Traumatol       Date:  2020-09-05

3.  Arthroscopic "Debridement and Implant Retention" With Local Administration of Exebacase (Lysin CF-301) Followed by Suppressive Tedizolid as Salvage Therapy in Elderly Patients for Relapsing Multidrug-Resistant S. epidermidis Prosthetic Knee Infection.

Authors:  Tristan Ferry; Cécile Batailler; Aubin Souche; Cara Cassino; Christian Chidiac; Thomas Perpoint; Claire le Corvaisier; Jérôme Josse; Romain Gaillard; Julien Roger; Camille Kolenda; Sébastien Lustig; Frédéric Laurent
Journal:  Front Med (Lausanne)       Date:  2021-05-14

4.  Medical innovations to maintain the function in patients with chronic PJI for whom explantation is not desirable: a pathophysiology-, multidisciplinary-, and experience-based approach.

Authors:  Tristan Ferry; Cécile Batailler; Sophie Brosset; Camille Kolenda; Sylvain Goutelle; Elliot Sappey-Marinier; Jérôme Josse; Frédéric Laurent; Sébastien Lustig
Journal:  SICOT J       Date:  2020-07-07

Review 5.  Coatings as the useful drug delivery system for the prevention of implant-related infections.

Authors:  Chenhao Pan; Zubin Zhou; Xiaowei Yu
Journal:  J Orthop Surg Res       Date:  2018-09-03       Impact factor: 2.359

6.  Treatment of a Recurrent Periprosthetic Joint Infection with an Intramedullary Knee Arthrodesis System with Low-Amount Metallic Silver Coating.

Authors:  Volker Alt; Christian Heiss; Markus Rupp
Journal:  J Bone Jt Infect       Date:  2019-04-20

Review 7.  Development of Silver-Containing Hydroxyapatite-Coated Antimicrobial Implants for Orthopaedic and Spinal Surgery.

Authors:  Tadatsugu Morimoto; Hirohito Hirata; Shuichi Eto; Akira Hashimoto; Sakumo Kii; Takaomi Kobayashi; Masatsugu Tsukamoto; Tomohito Yoshihara; Yu Toda; Masaaki Mawatari
Journal:  Medicina (Kaunas)       Date:  2022-04-06       Impact factor: 2.948

8.  Silver-coated modular Megaendoprostheses in salvage revision arthroplasty after periimplant infection with extensive bone loss - a pilot study of 34 patients.

Authors:  Dirk Zajonz; Undine Birke; Mohamed Ghanem; Torsten Prietzel; Christoph Josten; Andreas Roth; Johannes K M Fakler
Journal:  BMC Musculoskelet Disord       Date:  2017-09-02       Impact factor: 2.362

9.  Re-infection rates and clinical outcomes following arthrodesis with intramedullary nail and external fixator for infected knee prosthesis: a systematic review and meta-analysis.

Authors:  Giovanni Balato; Maria Rizzo; Tiziana Ascione; Francesco Smeraglia; Massimo Mariconda
Journal:  BMC Musculoskelet Disord       Date:  2018-10-10       Impact factor: 2.362

  9 in total

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