Literature DB >> 27181377

Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21.

Nitish Gulve1, Kirk Kimmerling2, Allen D Johnston3, Gerhard R Krueger4, Dharam V Ablashi5, Bhupesh K Prusty6.   

Abstract

We have created a novel quaternary ammonium silane, K21 through sol-gel chemistry, using an ethoxylated version of an organosilane quaternary ammonium compound and TetraEthyl Ortho Silicate (TEOS) as precursors. Previous studies using the precursor molecule quaternary ammonium compounds (QACs) and a methacryloxy version of K21, primarily designed for use in dental healthcare, have shown inhibited growth properties against several types of gram-positive and gram-negative bacteria including Escherichia coli, Streptococcus mutans, Actinomyces naeslundii and Candida albicans etc. Here we tested the effect of K21 on HSV-1, HHV-6A and HHV-7 in in vitro cell culture infection models. Our results show growth inhibitory effect of K21 on HSV-1, HHV-6A and HHV-7 infection.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Anti-viral; HHV-6; HHV-7; HSV-1; QAC

Mesh：

Substances：

Year:  2016        PMID： 27181377     DOI： 10.1016/j.antiviral.2016.05.004

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  6 in total

1.  Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA.

Authors:  Thomas Hennig; Archana B Prusty; Benedikt B Kaufer; Adam W Whisnant; Manivel Lodha; Antje Enders; Julius Thomas; Francesca Kasimir; Arnhild Grothey; Teresa Klein; Stefanie Herb; Christopher Jürges; Markus Sauer; Utz Fischer; Thomas Rudel; Gunter Meister; Florian Erhard; Lars Dölken; Bhupesh K Prusty
Journal:  Nature       Date:  2022-05-04       Impact factor: 49.962

2.  Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes.

Authors:  Joshua G Tweedy; Eric Escriva; Maya Topf; Ursula A Gompels
Journal:  Viruses       Date:  2017-12-31       Impact factor: 5.048

3.  A quaternary ammonium silane antimicrobial triggers bacterial membrane and biofilm destruction.

Authors:  Umer Daood; Jukka P Matinlinna; Malikarjuna Rao Pichika; Kit-Kay Mak; Venkateshbabu Nagendrababu; Amr S Fawzy
Journal:  Sci Rep       Date:  2020-07-03       Impact factor: 4.379

4.  HHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation.

Authors:  Bhupesh K Prusty; Nitish Gulve; Suvagata Roy Chowdhury; Michael Schuster; Sebastian Strempel; Vincent Descamps; Thomas Rudel
Journal:  NPJ Genom Med       Date:  2018-09-05       Impact factor: 8.617

5.  K21 Compound, a Potent Antifungal Agent: Implications for the Treatment of Fluconazole-Resistant HIV-Associated Candida Species.

Authors:  Cathy N John; Pedro M D S Abrantes; Bhupesh K Prusty; Dharam V Ablashi; Charlene W J Africa
Journal:  Front Microbiol       Date:  2019-05-24       Impact factor: 5.640

Review 6.  Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance.

Authors:  Yang Jiao; Li-Na Niu; Sai Ma; Jing Li; Franklin R Tay; Ji-Hua Chen
Journal:  Prog Polym Sci       Date:  2017-03-12       Impact factor: 29.190
  6 in total

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