Literature DB >> 27180180

Epigenetics: spotlight on type 2 diabetes and obesity.

A Desiderio1,2, R Spinelli1,2, M Ciccarelli1,2, C Nigro1,2, C Miele1,2, F Beguinot3,4, G A Raciti1,2.   

Abstract

Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity.

Entities:  

Keywords:  DNA methylation; Epigenetics; Obesity; Type 2 diabetes

Mesh：

Year:  2016        PMID： 27180180     DOI： 10.1007/s40618-016-0473-1

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  81 in total

1.  Twins and virtual twins: bases of relative body weight revisited.

Authors:  N L Segal; D B Allison
Journal:  Int J Obes Relat Metab Disord       Date:  2002-04

Review 2.  Small regulatory RNAs in mammals.

Authors:  John S Mattick; Igor V Makunin
Journal:  Hum Mol Genet       Date:  2005-04-15       Impact factor: 6.150

Review 3.  MicroRNA function in animal development.

Authors:  Erno Wienholds; Ronald H A Plasterk
Journal:  FEBS Lett       Date:  2005-08-10       Impact factor: 4.124

4.  Possible genomic imprinting of three human obesity-related genetic loci.

Authors:  Chuanhui Dong; Wei-Dong Li; Frank Geller; Lei Lei; Ding Li; Olga Y Gorlova; Johannes Hebebrand; Christopher I Amos; Robert D Nicholls; R Arlen Price
Journal:  Am J Hum Genet       Date:  2005-01-12       Impact factor: 11.025

5.  Developmental profile of homeobox gene expression during 3T3-L1 adipogenesis.

Authors:  R M Cowherd; R E Lyle; C P Miller; R E Mcgehee
Journal:  Biochem Biophys Res Commun       Date:  1997-08-18       Impact factor: 3.575

Review 6.  Minireview: Epigenetic programming of diabetes and obesity: animal models.

Authors:  Yoshinori Seki; Lyda Williams; Patricia M Vuguin; Maureen J Charron
Journal:  Endocrinology       Date:  2012-01-17       Impact factor: 4.736

7.  A model for obesity and gigantism due to disruption of the Ankrd26 gene.

Authors:  Tapan K Bera; Xiu-Fen Liu; Masanori Yamada; Oksana Gavrilova; Eva Mezey; Lino Tessarollo; Miriam Anver; Yoonsoo Hahn; Byungkook Lee; Ira Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-27       Impact factor: 11.205

8.  beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.

Authors:  U Ahlgren; J Jonsson; L Jonsson; K Simu; H Edlund
Journal:  Genes Dev       Date:  1998-06-15       Impact factor: 11.361

9.  The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study.

Authors:  R A Scott; C Langenberg; S J Sharp; P W Franks; O Rolandsson; D Drogan; Y T van der Schouw; U Ekelund; N D Kerrison; E Ardanaz; L Arriola; B Balkau; A Barricarte; I Barroso; B Bendinelli; J W J Beulens; H Boeing; B de Lauzon-Guillain; P Deloukas; G Fagherazzi; C Gonzalez; S J Griffin; L C Groop; J Halkjaer; J M Huerta; R Kaaks; K T Khaw; V Krogh; P M Nilsson; T Norat; K Overvad; S Panico; L Rodriguez-Suarez; D Romaguera; I Romieu; C Sacerdote; M J Sánchez; A M W Spijkerman; B Teucher; A Tjonneland; R Tumino; D L van der A; P A Wark; M I McCarthy; E Riboli; N J Wareham
Journal:  Diabetologia       Date:  2012-09-28       Impact factor: 10.122

10.  Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.

Authors:  C Ling; S Del Guerra; R Lupi; T Rönn; C Granhall; H Luthman; P Masiello; P Marchetti; L Groop; S Del Prato
Journal:  Diabetologia       Date:  2008-02-13       Impact factor: 10.122
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  9 in total

1.  Decreased expression of microRNAs targeting type-2 diabetes susceptibility genes in peripheral blood of patients and predisposed individuals.

Authors:  Ioanna Kokkinopoulou; Eirini Maratou; Panayota Mitrou; Eleni Boutati; Diamantis C Sideris; Emmanuel G Fragoulis; Maria-Ioanna Christodoulou
Journal:  Endocrine       Date:  2019-09-26       Impact factor: 3.633

2.  Polymorphism and methylation of the MC4R gene in obese and non-obese dogs.

Authors:  Monika Mankowska; Joanna Nowacka-Woszuk; Aneta Graczyk; Paulina Ciazynska; Monika Stachowiak; Marek Switonski
Journal:  Mol Biol Rep       Date:  2017-07-28       Impact factor: 2.316

Review 3.  Early-Life Nutritional Programming of Type 2 Diabetes: Experimental and Quasi-Experimental Evidence.

Authors:  Alexander M Vaiserman
Journal:  Nutrients       Date:  2017-03-05       Impact factor: 5.717

4.  Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity.

Authors:  Gregory A Raciti; Rosa Spinelli; Antonella Desiderio; Michele Longo; Luca Parrillo; Cecilia Nigro; Vittoria D'Esposito; Paola Mirra; Francesca Fiory; Vincenzo Pilone; Pietro Forestieri; Pietro Formisano; Ira Pastan; Claudia Miele; Francesco Beguinot
Journal:  Sci Rep       Date:  2017-03-07       Impact factor: 4.379

5.  Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity.

Authors:  Antonella Desiderio; Michele Longo; Luca Parrillo; Michele Campitelli; Giuseppe Cacace; Sonia de Simone; Rosa Spinelli; Federica Zatterale; Serena Cabaro; Pasquale Dolce; Pietro Formisano; Marco Milone; Claudia Miele; Francesco Beguinot; Gregory A Raciti
Journal:  Clin Epigenetics       Date:  2019-12-04       Impact factor: 6.551

Review 6.  Molecular basis of ageing in chronic metabolic diseases.

Authors:  R Spinelli; L Parrillo; M Longo; P Florese; A Desiderio; F Zatterale; C Miele; G Alexander Raciti; F Beguinot
Journal:  J Endocrinol Invest       Date:  2020-05-01       Impact factor: 4.256

Review 7.  Epigenetics of Aging and Aging-Associated Diseases.

Authors:  Dominik Saul; Robyn Laura Kosinsky
Journal:  Int J Mol Sci       Date:  2021-01-02       Impact factor: 5.923

Review 8.  DNA Methylation and Type 2 Diabetes: Novel Biomarkers for Risk Assessment?

Authors:  Gregory Alexander Raciti; Antonella Desiderio; Michele Longo; Alessia Leone; Federica Zatterale; Immacolata Prevenzano; Claudia Miele; Raffaele Napoli; Francesco Beguinot
Journal:  Int J Mol Sci       Date:  2021-10-28       Impact factor: 5.923

9.  Effect of diabetes status and hyperglycemia on global DNA methylation and hydroxymethylation.

Authors:  Jairo Arturo Pinzón-Cortés; Angelina Perna-Chaux; Nicolás Steven Rojas-Villamizar; Angélica Díaz-Basabe; Diana Carolina Polanía-Villanueva; María Fernanda Jácome; Carlos Olimpo Mendivil; Helena Groot; Valeriano López-Segura
Journal:  Endocr Connect       Date:  2017-10-09       Impact factor: 3.335
  9 in total

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