Duke Appiah1, Susan R Heckbert2, Mary Cushman3, Bruce M Psaty4, Aaron R Folsom5. 1. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA. Electronic address: dappiah@umn.edu. 2. Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA. 3. Department of Medicine, University of Vermont, Burlington, VT, USA. 4. Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA; Group Health Research Institute, Group Health Cooperatives, Seattle, WA, USA. 5. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Abstract
INTRODUCTION: The association of gamma prime (γ') fibrinogen; a fibrinogen γ chain variant generated via alternative mRNA processing, with cardiovascular disease (CVD) remains equivocal. We prospectively examine the association of plasma γ' fibrinogen with the incidence of multiple cardiovascular disease (CVD) endpoints, independent of established CVD risk factors and total fibrinogen. MATERIALS AND METHODS: We measured plasma γ' fibrinogen on plasma samples collected in 1992-1993 from adults ≥65years (n=3219) enrolled in the Cardiovascular Health Study, who were followed through 2013 for incident CVD events. RESULTS AND CONCLUSIONS: In multivariable Cox models adjusted for traditional CVD risk factors and total fibrinogen, the hazard ratio per 1 standard deviation (10.7mg/dl) increment of γ' fibrinogen was 1.02 (95%CI: 0.95-1.10) for coronary heart disease; 0.88 (0.77-1.00) for ischemic stroke; 1.07 (0.87-1.32) for peripheral artery disease; 1.00 (0.92-1.08) for heart failure and 1.01 (0.92-1.10) for CVD mortality. Likewise, we failed to show a statistically significant association of γ'/total fibrinogen ratio with any CVD endpoint. These results suggest that among the elderly, γ' fibrinogen does not add much to CVD prediction beyond traditional risk factors and total fibrinogen level.
INTRODUCTION: The association of gamma prime (γ') fibrinogen; a fibrinogen γ chain variant generated via alternative mRNA processing, with cardiovascular disease (CVD) remains equivocal. We prospectively examine the association of plasma γ' fibrinogen with the incidence of multiple cardiovascular disease (CVD) endpoints, independent of established CVD risk factors and total fibrinogen. MATERIALS AND METHODS: We measured plasma γ' fibrinogen on plasma samples collected in 1992-1993 from adults ≥65years (n=3219) enrolled in the Cardiovascular Health Study, who were followed through 2013 for incident CVD events. RESULTS AND CONCLUSIONS: In multivariable Cox models adjusted for traditional CVD risk factors and total fibrinogen, the hazard ratio per 1 standard deviation (10.7mg/dl) increment of γ' fibrinogen was 1.02 (95%CI: 0.95-1.10) for coronary heart disease; 0.88 (0.77-1.00) for ischemic stroke; 1.07 (0.87-1.32) for peripheral artery disease; 1.00 (0.92-1.08) for heart failure and 1.01 (0.92-1.10) for CVD mortality. Likewise, we failed to show a statistically significant association of γ'/total fibrinogen ratio with any CVD endpoint. These results suggest that among the elderly, γ' fibrinogen does not add much to CVD prediction beyond traditional risk factors and total fibrinogen level.
Authors: Rehana S Lovely; Steven C Kazmierczak; Joseph M Massaro; Ralph B D'Agostino; Christopher J O'Donnell; David H Farrell Journal: Clin Chem Date: 2010-03-26 Impact factor: 8.327
Authors: D G Ives; A L Fitzpatrick; D E Bild; B M Psaty; L H Kuller; P M Crowley; R G Cruise; S Theroux Journal: Ann Epidemiol Date: 1995-07 Impact factor: 3.797
Authors: M N Mannila; R S Lovely; S C Kazmierczak; P Eriksson; A Samnegård; D H Farrell; A Hamsten; A Silveira Journal: J Thromb Haemost Date: 2007-01-22 Impact factor: 5.824
Authors: Elim Y L Cheung; Shirley Uitte de Willige; Hans L Vos; Frank W G Leebeek; Diederik W J Dippel; Rogier M Bertina; Moniek P M de Maat Journal: Stroke Date: 2008-01-31 Impact factor: 7.914
Authors: Bruce M Psaty; Joseph A Delaney; Alice M Arnold; Lesley H Curtis; Annette L Fitzpatrick; Susan R Heckbert; Barbara McKnight; Diane Ives; John S Gottdiener; Lewis H Kuller; W T Longstreth Journal: Circulation Date: 2015-11-04 Impact factor: 29.690
Authors: Rehana S Lovely; Lisa A Falls; Hamid A Al-Mondhiry; Charles E Chambers; Gary J Sexton; Hanyu Ni; David H Farrell Journal: Thromb Haemost Date: 2002-07 Impact factor: 5.249
Authors: Jacob E Crawford; Ricardo Amaru; Jihyun Song; Colleen G Julian; Fernando Racimo; Jade Yu Cheng; Xiuqing Guo; Jie Yao; Bharath Ambale-Venkatesh; João A Lima; Jerome I Rotter; Josef Stehlik; Lorna G Moore; Josef T Prchal; Rasmus Nielsen Journal: Am J Hum Genet Date: 2017-11-02 Impact factor: 11.025
Authors: Jillian Maners; Dipender Gill; Nathan Pankratz; Michael A Laffan; Alisa S Wolberg; Moniek P M de Maat; Symen Ligthart; Weihong Tang; Cavin K Ward-Caviness; Myriam Fornage; Stephanie Debette; Martin Dichgans; Barbara McKnight; Eric Boerwinkle; Nicholas L Smith; Alanna C Morrison; Abbas Dehghan; Paul S de Vries Journal: Blood Date: 2020-12-24 Impact factor: 22.113