Literature DB >> 27179939

A distribution analysis of action potential parameters obtained from patch-clamped human stem cell-derived cardiomyocytes.

Fernando López-Redondo1, Junko Kurokawa2, Fumimasa Nomura3, Tomoyuki Kaneko4, Tomoyo Hamada3, Tetsushi Furukawa5, Kenji Yasuda3.   

Abstract

We investigated electrophysiological properties of human induced-pluripotent-stem-cell-derived and embryonic-stem-cell-derived cardiomyocytes, and analyzed action potential parameters by plotting their frequency distributions. In the both cell lines, the distribution analysis revealed that histograms of maximum upstroke velocity showed two subpopulations with similar intersection values. Sub-populations with faster maximum upstroke velocity showed significant prolongation of action potential durations by application of E-4031, whereas others did not, which may be partly due to shallower maximum diastolic potentials. We described electrophysiological and pharmacological properties of stem-cell-derived cardiomyocytes in the respective sub-populations, which provides a way to characterize diverse electrical properties of stem-cell-derived cardiomyocytes systematically.
Copyright © 2016 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cardiomyocyte; Patch-clamp; iPS cells

Mesh：

Year:  2016        PMID： 27179939     DOI： 10.1016/j.jphs.2016.04.015

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  9 in total

Review 1.  Dominant rule of community effect in synchronized beating behavior of cardiomyocyte networks.

Authors:  Kenji Yasuda
Journal:  Biophys Rev       Date:  2020-05-04

2.  Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology.

Authors:  Chon Lok Lei; Ken Wang; Michael Clerx; Ross H Johnstone; Maria P Hortigon-Vinagre; Victor Zamora; Andrew Allan; Godfrey L Smith; David J Gavaghan; Gary R Mirams; Liudmila Polonchuk
Journal:  Front Physiol       Date:  2017-12-12       Impact factor: 4.566

3.  On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development.

Authors:  Yumiko Asahi; Tomoyo Hamada; Akihiro Hattori; Kenji Matsuura; Masao Odaka; Fumimasa Nomura; Tomoyuki Kaneko; Yasuyuki Abe; Kiyoshi Takasuna; Atsushi Sanbuissho; Kenji Yasuda
Journal:  Sci Rep       Date:  2018-09-28       Impact factor: 4.379

4.  Emergent synchronous beating behavior in spontaneous beating cardiomyocyte clusters.

Authors:  Kazufumi Sakamoto; Yoshitsune Hondo; Naoki Takahashi; Yuhei Tanaka; Rikuto Sekine; Kenji Shimoda; Haruki Watanabe; Kenji Yasuda
Journal:  Sci Rep       Date:  2021-06-04       Impact factor: 4.379

5.  Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes.

Authors:  Aleksandra Nijak; Eline Simons; Bert Vandendriessche; Dieter Van de Sande; Erik Fransen; Ewa Sieliwończyk; Ilse Van Gucht; Emeline Van Craenenbroeck; Johan Saenen; Hein Heidbuchel; Peter Ponsaerts; Alain J Labro; Dirk Snyders; Winnok De Vos; Dorien Schepers; Maaike Alaerts; Bart L Loeys
Journal:  Biol Open       Date:  2022-02-23       Impact factor: 2.422

6.  Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy.

Authors:  Matthew Wheelwright; Zaw Win; Jennifer L Mikkila; Kamilah Y Amen; Patrick W Alford; Joseph M Metzger
Journal:  PLoS One       Date:  2018-04-04       Impact factor: 3.240

7.  Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac Electrophysiology.

Authors:  Louise A Bowler; David J Gavaghan; Gary R Mirams; Jonathan P Whiteley
Journal:  Bull Math Biol       Date:  2018-10-05       Impact factor: 1.758

8.  Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts.

Authors:  Dominic Filice; Wahiba Dhahri; Joell L Solan; Paul D Lampe; Erin Steele; Nikita Milani; Benjamin Van Biber; Wei-Zhong Zhu; Tamilla Sadikov Valdman; Rocco Romagnuolo; José David Otero-Cruz; Kip D Hauch; Matthew W Kay; Narine Sarvazyan; Michael A Laflamme
Journal:  Stem Cell Res Ther       Date:  2020-09-25       Impact factor: 6.832

Review 9.  Human Induced Pluripotent Stem Cells as a Disease Model System for Heart Failure.

Authors:  Anton Deicher; Timon Seeger
Journal:  Curr Heart Fail Rep       Date:  2020-11-19
  9 in total

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