Nicola Veronese1, Emanuele Cereda2, Stefania Maggi3, Claudio Luchini4, Marco Solmi5, Toby Smith6, Michael Denkinger7, Michael Hurley8, Trevor Thompson9, Enzo Manzato10, Giuseppe Sergi1, Brendon Stubbs11. 1. Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy. 2. Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 3. Aging Branch, Institute of Neuroscience, National Research Council-CNR, Padova, Italy. 4. Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy. 5. Department of Neurosciences, University of Padova, Padova, Italy; Local Health Unit 17, Mental Health Department, Padova, Italy. 6. Faculty of Medicine and Health Sciences, School of Health Sciences, University of East Anglia, Norwich, UK. 7. Geriatric Research Unit, Agaplesion Bethesda Clinic, University of Ulm, Ulm, Germany; Geriatric Centre Ulm/Alb-Donau, Ulm University, Ulm, Germany. 8. Faculty of Health and Social Care Sciences, St Georges University of London, London, UK. 9. Faculty of Education and Health, University of Greenwich, London, UK. 10. Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy; Aging Branch, Institute of Neuroscience, National Research Council-CNR, Padova, Italy. 11. Health Service and Population Research Department, Institute of Psychiatry, King's College London, London, UK; Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK. Electronic address: brendon.stubbs@kcl.ac.uk.
Abstract
OBJECTIVES: Osteoarthritis (OA) is a leading cause of disability, but the relationship with premature mortality remains uncertain. We aimed to investigate the relationship between OA and mortality from any cause and from cardiovascular disease (CVD). METHODS: Electronic literature databases searches were conducted to identify prospective studies comparing mortality in a sample of people with and without OA. Risk of all-cause and CVD mortality were summarized using adjusted hazard ratios (HRs) for joint specific (hand, hip, and knee) and joint non-specific OA. New data from the Progetto Veneto Anziani (PRO.V.A.) study were also included. RESULTS: From the PRO.V.A. study (N = 2927), there was no significant increase in mortality risk for participants with any joint OA (N = 1858) compared to non-OA (all-cause, HR = 0.95, 95% CI: 0.77-1.15 and CVD, HR = 1.12, 95% CI: 0.82-1.54). On meta-analysis, seven studies (OA = 10,018/non-OA = 18,541), with a median 12-year follow-up, reported no increased risk of any-cause mortality in those with OA (HR = 1.10, 95% CI: 0.97-1.25). After removing data on hand OA, a significant association between OA and mortality was observed (HR = 1.18, 95% CI: 1.08-1.28). There was a significant higher risk of overall mortality for (1) studies conducted in Europe, (2) patients with multi-joint OA; and (3) a radiological diagnosis of OA. OA was associated with significantly higher CVD mortality (HR = 1.21, 95% CI: 1.10-1.34). CONCLUSIONS: People with OA are at increased risk of death due to CVD. The relationship with overall mortality is less clear and may be moderated by the presence of hand OA.
OBJECTIVES:Osteoarthritis (OA) is a leading cause of disability, but the relationship with premature mortality remains uncertain. We aimed to investigate the relationship between OA and mortality from any cause and from cardiovascular disease (CVD). METHODS: Electronic literature databases searches were conducted to identify prospective studies comparing mortality in a sample of people with and without OA. Risk of all-cause and CVD mortality were summarized using adjusted hazard ratios (HRs) for joint specific (hand, hip, and knee) and joint non-specific OA. New data from the Progetto Veneto Anziani (PRO.V.A.) study were also included. RESULTS: From the PRO.V.A. study (N = 2927), there was no significant increase in mortality risk for participants with any joint OA (N = 1858) compared to non-OA (all-cause, HR = 0.95, 95% CI: 0.77-1.15 and CVD, HR = 1.12, 95% CI: 0.82-1.54). On meta-analysis, seven studies (OA = 10,018/non-OA = 18,541), with a median 12-year follow-up, reported no increased risk of any-cause mortality in those with OA (HR = 1.10, 95% CI: 0.97-1.25). After removing data on hand OA, a significant association between OA and mortality was observed (HR = 1.18, 95% CI: 1.08-1.28). There was a significant higher risk of overall mortality for (1) studies conducted in Europe, (2) patients with multi-joint OA; and (3) a radiological diagnosis of OA. OA was associated with significantly higher CVD mortality (HR = 1.21, 95% CI: 1.10-1.34). CONCLUSIONS:People with OA are at increased risk of death due to CVD. The relationship with overall mortality is less clear and may be moderated by the presence of hand OA.
Authors: R J Cleveland; C Alvarez; T A Schwartz; E Losina; J B Renner; J M Jordan; L F Callahan Journal: Osteoarthritis Cartilage Date: 2018-12-22 Impact factor: 6.576
Authors: R J Cleveland; C Alvarez; A E Nelson; T A Schwartz; J B Renner; J M Jordan; L F Callahan Journal: Osteoarthritis Cartilage Date: 2020-08-07 Impact factor: 6.576
Authors: Paola Siviero; Nicola Veronese; Toby Smith; Brendon Stubbs; Federica Limongi; Sabina Zambon; Elaine M Dennison; Mark Edwards; Cyrus Cooper; Erik J Timmermans; Natasja M van Schoor; Suzan van der Pas; Laura A Schaap; Michael D Denkinger; Richard Peter; Florian Herbolsheimer; Ángel Otero; Maria Victoria Castell; Nancy L Pedersen; Dorly J H Deeg; Stefania Maggi Journal: J Am Geriatr Soc Date: 2019-09-17 Impact factor: 5.562