Thomas F Imperiale1, Douglas K Rex2. 1. Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Regenstrief Institute, Inc., Indianapolis, Indiana, USA; Center for Innovation, Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, USA. Electronic address: timperia@iu.edu. 2. Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.