Emre Bora1, Stefano Meletti2. 1. The Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, VIC, Australia. Electronic address: ibora@unimelb.edu.au. 2. Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurology Unit, NOCSAE Hospital, AUSL Modena, Italy.
Abstract
Objective: There is increasing evidence suggesting that social cognitive abilities are impaired in temporal lobe epilepsy (TLE), the most common form of focal epilepsies. Methods: In this meta-analysis, 31 studies investigating theory of mind (ToM) and facial emotion recognition performances of 1356 patients with TLE (351 postsurgery) and 859 healthy controls were included. Results: Patients with TLE had significant deficits in ToM (d = 0.73–0.89) and recognition of facial emotions. There were no significant differences in severity of social cognitive deficits between patients with TLE with or without medial temporal lobectomy. Earlier onset of seizures was associated with ToM impairment. Right-sided TLE was associated with more severe deficits in recognition of fear, sadness, and disgust. Conclusions: Social cognitive information processing is impaired in TLE, and the potential role of these deficits in functional impairment needs to be further investigated.
Objective: There is increasing evidence suggesting that social cognitive abilities are impaired in temporal lobe epilepsy (TLE), the most common form of focal epilepsies. Methods: In this meta-analysis, 31 studies investigating theory of mind (ToM) and facial emotion recognition performances of 1356 patients with TLE (351 postsurgery) and 859 healthy controls were included. Results:Patients with TLE had significant deficits in ToM (d = 0.73–0.89) and recognition of facial emotions. There were no significant differences in severity of social cognitive deficits between patients with TLE with or without medial temporal lobectomy. Earlier onset of seizures was associated with ToM impairment. Right-sided TLE was associated with more severe deficits in recognition of fear, sadness, and disgust. Conclusions: Social cognitive information processing is impaired in TLE, and the potential role of these deficits in functional impairment needs to be further investigated.
Entities:
Keywords:
Emotion recognition; Social cognition; Temporal lobe epilepsy; Theory of mind
Authors: Łukasz Okruszek; Aleksandra Bala; Małgorzata Wordecha; Michał Jarkiewicz; Adam Wysokiński; Ewa Szczepocka; Aleksandra Piejka; Oliwia Zaborowska; Marta Szantroch; Andrzej Rysz; Andrzej Marchel Journal: Sci Rep Date: 2017-03-28 Impact factor: 4.379
Authors: Grace E Rice; Paul Hoffman; Richard J Binney; Matthew A Lambon Ralph Journal: Philos Trans R Soc Lond B Biol Sci Date: 2018-08-05 Impact factor: 6.671