J C Prinz1. 1. Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Ludwig-Maximilians-Universität, Frauenlobstr. 9-11, 80337, München, Deutschland. joerg.prinz@med.uni-muenchen.de.
Abstract
BACKGROUND: Psoriasis is a human leukocyte antigen (HLA)-associated T‑cell-mediated disorder. OBJECTIVES: The role of the main psoriasis risk allele HLA-C*06:02 in disease manifestation and the mechanisms which activate the pathogenic T‑cell response in the skin of psoriasis patients remained elusive. MATERIALS AND METHODS: Key to the immune pathogenesis of psoriasis was the analysis of the specificity of the infiltrating lesional psoriatic CD8(+) T cells RESULTS AND CONCLUSION: Analyses of the lesional psoriatic T‑cell reactivity demonstrate that psoriasis is an autoimmune disease. It is based on an autoimmune response against melanocytes which is preferentially mediated by HLA-C*06:02 through autoantigen presentation. Here we discuss the mechanisms of this autoimmune response in the context of the polygenic psoriatic predisposition.
BACKGROUND:Psoriasis is a human leukocyte antigen (HLA)-associated T‑cell-mediated disorder. OBJECTIVES: The role of the main psoriasis risk allele HLA-C*06:02 in disease manifestation and the mechanisms which activate the pathogenic T‑cell response in the skin of psoriasispatients remained elusive. MATERIALS AND METHODS: Key to the immune pathogenesis of psoriasis was the analysis of the specificity of the infiltrating lesional psoriatic CD8(+) T cells RESULTS AND CONCLUSION: Analyses of the lesional psoriatic T‑cell reactivity demonstrate that psoriasis is an autoimmune disease. It is based on an autoimmune response against melanocytes which is preferentially mediated by HLA-C*06:02 through autoantigen presentation. Here we discuss the mechanisms of this autoimmune response in the context of the polygenic psoriatic predisposition.
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Authors: David A Jones; Nikhil Yawalkar; Ki-Young Suh; Sara Sadat; Benjamin Rich; Thomas S Kupper Journal: J Invest Dermatol Date: 2004-07 Impact factor: 8.551
Authors: A Menssen; P Trommler; S Vollmer; D Schendel; E Albert; L Gürtler; G Riethmüller; J C Prinz Journal: J Immunol Date: 1995-10-15 Impact factor: 5.422
Authors: Ulrike Hüffmeier; Steffen Uebe; Arif B Ekici; John Bowes; Emiliano Giardina; Eleanor Korendowych; Kristina Juneblad; Maria Apel; Ross McManus; Pauline Ho; Ian N Bruce; Anthony W Ryan; Frank Behrens; Jesús Lascorz; Beate Böhm; Heiko Traupe; Jörg Lohmann; Christian Gieger; Heinz-Erich Wichmann; Christine Herold; Michael Steffens; Lars Klareskog; Thomas F Wienker; Oliver Fitzgerald; Gerd-Marie Alenius; Neil J McHugh; Giuseppe Novelli; Harald Burkhardt; Anne Barton; André Reis Journal: Nat Genet Date: 2010-10-17 Impact factor: 38.330