Christopher B Highley1, Miju Kim2, Daeyeon Lee2, Jason A Burdick1. 1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. 2. Department of Chemical & Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract
AIM: To develop a stimulus-responsive material platform capable of releasing entrapped molecules in response to near infrared (NIR) light. MATERIALS & METHODS: Gold nanorods were mixed with hyaluronic acid derivatives modified with β-cyclodextrin or adamantane to create a NIR-responsive hydrogel-nanorod composite. Microfluidics were used to create responsive microgels and NIR-triggered release was evaluated. RESULTS & DISCUSSION: The hydrogel-nanorod composite material exhibited a rapid response to NIR-irradiation, allowing enhanced release of encapsulated payloads with material heating and network disruption. The release was dependent on the entrapped molecule size, the NIR exposure time and the light intensity. CONCLUSION: NIR irradiation of hydrogel-nanorods leads to plasmonic heating and triggered release of encapsulated molecules, a system that has potential for light-triggered release of therapeutics.
AIM: To develop a stimulus-responsive material platform capable of releasing entrapped molecules in response to near infrared (NIR) light. MATERIALS & METHODS: Gold nanorods were mixed with hyaluronic acid derivatives modified with β-cyclodextrin or adamantane to create a NIR-responsive hydrogel-nanorod composite. Microfluidics were used to create responsive microgels and NIR-triggered release was evaluated. RESULTS & DISCUSSION: The hydrogel-nanorod composite material exhibited a rapid response to NIR-irradiation, allowing enhanced release of encapsulated payloads with material heating and network disruption. The release was dependent on the entrapped molecule size, the NIR exposure time and the light intensity. CONCLUSION: NIR irradiation of hydrogel-nanorods leads to plasmonic heating and triggered release of encapsulated molecules, a system that has potential for light-triggered release of therapeutics.
Entities:
Keywords:
drug delivery; hydrogels; light; nanorods; stimuli
Authors: Teresa L Rapp; Christopher B Highley; Brian C Manor; Jason A Burdick; Ivan J Dmochowski Journal: Chemistry Date: 2018-01-10 Impact factor: 5.236