Daniel Cortez1,2, Sharon Graw3, Luisa Mestroni3. 1. Department of Pediatric Cardiology, Children's Hospital of Colorado/University of Colorado, Aurora, Colorado. 2. Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden. 3. Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado.
Abstract
BACKGROUND: The spatial peaks QRS-T (SPQRS-T) angle differentiates hypertrophic cardiomyopathy (HCM) patients from controls. Increased angle confers arrhythmia risk in other populations. HYPOTHESIS: We predict that the SPQRS-T angle will identify HCM patients with sustained ventricular arrhythmias (VAs) and those with New York Heart Association class III/IV heart failure. METHODS: Corrected QT interval, QRS duration, and SPQRS-T angle were assessed in HCM patients with VAs (>30 seconds) and those without VAs. RESULTS: One hundred HCM patients (mean age, 32.7 ± 17.2 years) were assessed. Twenty patients had VAs. The corrected QT interval identified VA (P = 0.018) and at 460 ms gave positive and negative predictive values of 28.6% and 83.3%, respectively, and an odds ratio of 2.0 (95% confidence interval: 0.7-5.6). The SPQRS-T angle differentiated VA from no VA (P < 0.001) and at 124.1 degrees gave positive and negative predictive values and an odds ratio of 36.7%, 96.1%, and 14.2 (95% confidence interval: 3.1-65.6), respectively. CONCLUSIONS: The SPQRS-T angle best differentiated patients with VAs.
BACKGROUND: The spatial peaks QRS-T (SPQRS-T) angle differentiates hypertrophic cardiomyopathy (HCM) patients from controls. Increased angle confers arrhythmia risk in other populations. HYPOTHESIS: We predict that the SPQRS-T angle will identify HCM patients with sustained ventricular arrhythmias (VAs) and those with New York Heart Association class III/IV heart failure. METHODS: Corrected QT interval, QRS duration, and SPQRS-T angle were assessed in HCM patients with VAs (>30 seconds) and those without VAs. RESULTS: One hundred HCM patients (mean age, 32.7 ± 17.2 years) were assessed. Twenty patients had VAs. The corrected QT interval identified VA (P = 0.018) and at 460 ms gave positive and negative predictive values of 28.6% and 83.3%, respectively, and an odds ratio of 2.0 (95% confidence interval: 0.7-5.6). The SPQRS-T angle differentiated VA from no VA (P < 0.001) and at 124.1 degrees gave positive and negative predictive values and an odds ratio of 36.7%, 96.1%, and 14.2 (95% confidence interval: 3.1-65.6), respectively. CONCLUSIONS: The SPQRS-T angle best differentiated patients with VAs.
Authors: Christoph Julian Jensen; Moritz Lambers; Behnam Zadeh; Jan Martin Wambach; Kai Nassenstein; Oliver Bruder Journal: Int J Med Sci Date: 2021-01-01 Impact factor: 3.738
Authors: Andrzej Jaroszyński; Jacek Furmaga; Tomasz Zapolski; Tomasz Zaborowski; Sławomir Rudzki; Wojciech Dąbrowski Journal: BMC Nephrol Date: 2019-12-02 Impact factor: 2.388