BACKGROUND: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. MATERIALS & METHODS: We used dithiocarbamate-functionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. RESULTS: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. CONCLUSION: Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy.
BACKGROUND: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. MATERIALS & METHODS: We used dithiocarbamate-functionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. RESULTS: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. CONCLUSION:Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy.
Entities:
Keywords:
cancer therapy; drug delivery; nanocapsule; paclitaxel; sustained drug release
Authors: Cheng Wang; Zongxi Li; Dennis Cao; Yan-Li Zhao; Justin W Gaines; O Altan Bozdemir; Michael W Ambrogio; Marco Frasconi; Youssry Y Botros; Jeffrey I Zink; J Fraser Stoddart Journal: Angew Chem Int Ed Engl Date: 2012-04-13 Impact factor: 15.336
Authors: Xiao-Chao Yang; Bappaditya Samanta; Sarit S Agasti; Youngdo Jeong; Zheng-Jiang Zhu; Subinoy Rana; Oscar R Miranda; Vincent M Rotello Journal: Angew Chem Int Ed Engl Date: 2011-01-10 Impact factor: 15.336
Authors: Daniel P Ferris; Jie Lu; Chris Gothard; Rolando Yanes; Courtney R Thomas; John-Carl Olsen; J Fraser Stoddart; Fuyuhiko Tamanoi; Jeffrey I Zink Journal: Small Date: 2011-05-19 Impact factor: 13.281
Authors: Uma Prabhakar; Hiroshi Maeda; Rakesh K Jain; Eva M Sevick-Muraca; William Zamboni; Omid C Farokhzad; Simon T Barry; Alberto Gabizon; Piotr Grodzinski; David C Blakey Journal: Cancer Res Date: 2013-02-19 Impact factor: 12.701
Authors: Véronique Mathieu; Christine Pirker; Wolfgang M Schmidt; Sabine Spiegl-Kreinecker; Daniela Lötsch; Petra Heffeter; Balazs Hegedus; Michael Grusch; Robert Kiss; Walter Berger Journal: Oncotarget Date: 2012-04
Authors: Seyoung Hong; Dong Wook Choi; Hong Nam Kim; Chun Gwon Park; Wonhwa Lee; Hee Ho Park Journal: Pharmaceutics Date: 2020-06-29 Impact factor: 6.321