Literature DB >> 27175354

Determination of 50% endpoint titer using a simple formula.

Muthannan Andavar Ramakrishnan1.   

Abstract

Two commonly used methods for calculating 50% endpoint using serial dilutions are Spearman-Karber method and Reed and Muench method. To understand/apply the above formulas, moderate statistical/mathematical skills are necessary. In this paper, a simple formula/method for calculating 50% endpoints has been proposed. The formula yields essentially similar results as those of the Spearman-Karber method. The formula has been rigorously evaluated with several samples.

Keywords:  Endpoint dilution; Reed and Muench; Spearman-Karber; TCID50

Year:  2016        PMID： 27175354      PMCID： PMC4861875          DOI： 10.5501/wjv.v5.i2.85

Source DB:  PubMed          Journal:  World J Virol        ISSN： 2220-3249


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