| Literature DB >> 27174447 |
Vanessa Brouard1, Isabelle Guénon1, Hélène Bouraima-Lelong1, Christelle Delalande2.
Abstract
Several studies have highlighted the negative effects of bisphenol A (BPA), a chemical compound with estrogenic activity, on reproductive health. To elucidate the impact of BPA on spermatogenesis' establishment and mechanisms of action of BPA and 17β-estradiol (E2), as both can be found in the environment, we exposed rats to BPA (50μg/kg bw/day of BPA), E2 (20μg/kg bw/day of E2) and BPA+E2 from 15 to 30days post-partum. Histological and gene expression studies revealed that BPA and BPA+E2 exposures promoted spermatogenesis establishment whereas E2 alone delayed it. Then, a decrease in gene expression of blood-testis-barrier (BTB) proteins was observed in all treated groups. Therefore, our study has demonstrated a differential effect of BPA and E2 exposures on spermatogenesis establishment in prepubertal rats and a deleterious effect of these chemicals on BTB establishment. Thus, the effects of BPA seem to be mediated by receptors other than estrogen receptors.Entities:
Keywords: Bisphenol A (BPA); Blood testis barrier (BTB); Estradiol (E2); Spermatogenesis
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Year: 2016 PMID： 27174447 DOI： 10.1016/j.reprotox.2016.05.003
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143