| Literature DB >> 27174169 |
Aroma Agape Gopalai1, Azlina Ahmad-Annuar1, Hui-Hua Li2, Yi Zhao3, Shen-Yang Lim4, Ai Huey Tan4, Thien Thein Lim5, Gaik Bee Eow6, Puvanarajah Santhi7, Viswanathan Shanthi7, Mohamed Ibrahim Norlinah8, Zariah Abdul Aziz9, Soo Kun Lim4, Chong Tin Tan4, Eng-King Tan10,11.
Abstract
PARK16 was identified as a risk factor for Parkinson's disease in a Japanese cohort; however, subsequent studies in the other populations including the Chinese, European, Caucasian, and Chilean have shown a protective role instead. To investigate this locus in our Malaysian cohort, 1,144 individuals were screened for five SNPs in the PARK16 locus and logistic regression analysis showed that the A allele of the rs947211 SNP reduced the risk of developing PD via a recessive model (Odds ratio 0.57, P-value 0.0003). Pooled analysis with other Asian studies showed that A allele of the rs947211 SNP decreased the risk of developing PD via a recessive model (Odds ratio 0.71, P-value 0.0001). In addition, when meta-analysis was performed with other Asian population, three SNPs (rs823128, rs823156, and rs11240572) reduced risk of developing PD via a dominant model.Entities:
Keywords: Malaysia; PARK16; Parkinson's disease; genetics; meta-analysis
Mesh：
Year: 2016 PMID： 27174169 DOI： 10.1002/ajmg.b.32454
Source DB: PubMed Journal: Am J Med Genet B Neuropsychiatr Genet ISSN： 1552-4841 Impact factor: 3.568