Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension.

Literature DB >> 2717409

Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension.

E M McNally¹, P M Buttrick, L A Leinwand.

Abstract

Cardiac myosin heavy chain (MHC) isoform distribution has been shown to undergo changes during development, in response to hormonal stimuli, and during pathologic states like hypertension. We initiated a study of myosin light chain 1 (MLC1) expression in cardiac tissue to determine whether MLC1 undergoes changes similar to those seen for MHC. We isolated a full length cDNA for the predominant MLC1 sequence in rat hearts. This gene is expressed in ventricular tissue at much higher levels than in atrial tissue. Based on its expression pattern and sequence homology, this cDNA encodes the rat ventricular MLC1 and has been named RVMLC1. RVMLC1 is expressed at very low levels in cardiac tissue during early development and is expressed abundantly after birth and in adult hearts. The expression of RVMLC1 was found not to change in the hearts of rats with renovascular hypertension.

Entities: Disease Gene Species

Mesh：

Substances：
DNA
Myosins

Year: 1989 PMID： 2717409 PMCID： PMC317655 DOI： 10.1093/nar/17.7.2753

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

36 in total

Review 1. The function of myosin and myosin light chain kinase phosphorylation in smooth muscle.

Authors: K E Kamm; J T Stull
Journal: Annu Rev Pharmacol Toxicol Date: 1985 Impact factor: 13.820

2. Using mini-prep plasmid DNA for sequencing double stranded templates with Sequenase.

Authors: R Kraft; J Tardiff; K S Krauter; L A Leinwand
Journal: Biotechniques Date: 1988-06 Impact factor: 1.993

3. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.

Authors: S Henikoff
Journal: Gene Date: 1984-06 Impact factor: 3.688

4. Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

Authors: A M Lompré; B Nadal-Ginard; V Mahdavi
Journal: J Biol Chem Date: 1984-05-25 Impact factor: 5.157

5. Local changes in myosin types in diseased human atrial myocardium: a quantitative immunofluorescence study.

Authors: P Bouvagnet; J Léger; C A Dechesne; G Dureau; M Anoal; J J Léger
Journal: Circulation Date: 1985-08 Impact factor: 29.690

6. Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.

Authors: V Mahdavi; A P Chambers; B Nadal-Ginard
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

7. Structure and sequence of the myosin alkali light chain gene expressed in adult cardiac atria and fetal striated muscle.

Authors: P J Barton; B Robert; A Cohen; I Garner; D Sassoon; A Weydert; M E Buckingham
Journal: J Biol Chem Date: 1988-09-05 Impact factor: 5.157

8. The myosin alkali light chains of mouse ventricular and slow skeletal muscle are indistinguishable and are encoded by the same gene.

Authors: P J Barton; A Cohen; B Robert; M Y Fiszman; F Bonhomme; J L Guénet; D P Leader; M E Buckingham
Journal: J Biol Chem Date: 1985-07-15 Impact factor: 5.157

9. A single locus in the mouse encodes both myosin light chains 1 and 3, a second locus corresponds to a related pseudogene.

Authors: B Robert; P Daubas; M A Akimenko; A Cohen; I Garner; J L Guenet; M Buckingham
Journal: Cell Date: 1984-11 Impact factor: 41.582

10. Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.

Authors: M Periasamy; E E Strehler; L I Garfinkel; R M Gubits; N Ruiz-Opazo; B Nadal-Ginard
Journal: J Biol Chem Date: 1984-11-10 Impact factor: 5.157

11 in total

Review 1. Myosin light chains and troponin C: structural and evolutionary relationships revealed by amino acid sequence comparisons.

Authors: J H Collins
Journal: J Muscle Res Cell Motil Date: 1991-02 Impact factor: 2.698

Review 2. Evolution of EF-hand calcium-modulated proteins. II. Domains of several subfamilies have diverse evolutionary histories.

Authors: S Nakayama; N D Moncrief; R H Kretsinger
Journal: J Mol Evol Date: 1992-05 Impact factor: 2.395

3. Role of essential light chain EF hand domains in calcium binding and regulation of scallop myosin.

Authors: S Fromherz; A G Szent-Györgyi
Journal: Proc Natl Acad Sci U S A Date: 1995-08-15 Impact factor: 11.205

4. Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific.

Authors: Huamei He; Kirsten Hoyer; Hai Tao; Ronald Rice; Jesus Jimenez; Jil C Tardiff; Joanne S Ingwall
Journal: J Physiol Date: 2012-08-20 Impact factor: 5.182

5. Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension.

Authors: A S Rovner; E M McNally; L A Leinwand
Journal: Nucleic Acids Res Date: 1990-03-25 Impact factor: 16.971

6. Human cardiac myosin light chains: sequence comparisons between myosin LC1 and LC2 from normal and idiopathic dilated cardiomyopathic hearts.

Authors: J C Holt; J B Caulfield; P Norton; P D Chantler; H S Slayter; S S Margossian
Journal: Mol Cell Biochem Date: 1995-04-12 Impact factor: 3.396