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Literature DB >> 27174043

Molecular genetics of thyroid cancer.

Abstract

The pathogenesis of the development and progression of thyroid cancer (TC) is far from being clear at present. Accumulated evidence suggests that it is a complex polygenic disorder for which genetic factors play an important role in disease aetiology. Here we review the literature to report the genetic variations and alterations that have been described in the aetiology of TC. The functional effects of some mutations and single nucleotide polymorphisms on TC are validated, establishing the role of sequence variations in this cancer. However, large prospective studies are still required to evaluate the diagnostic and prognostic value of these genetic determinants in clinical practice.

Entities: Disease

Mesh：

Year: 2016 PMID： 27174043 PMCID： PMC6865173 DOI： 10.1017/S0016672316000057

Source DB: PubMed Journal: Genet Res (Camb) ISSN： 0016-6723 Impact factor: 1.588

83 in total

1. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.

Authors: Meiko Takahashi; Vladimir A Saenko; Tatiana I Rogounovitch; Takahisa Kawaguchi; Valentina M Drozd; Hisako Takigawa-Imamura; Natallia M Akulevich; Chanavee Ratanajaraya; Norisato Mitsutake; Noboru Takamura; Larisa I Danilova; Maxim L Lushchik; Yuri E Demidchik; Simon Heath; Ryo Yamada; Mark Lathrop; Fumihiko Matsuda; Shunichi Yamashita
Journal: Hum Mol Genet Date: 2010-03-29 Impact factor: 6.150

2. The BRAF mutation is predictive of aggressive clinicopathological characteristics in papillary thyroid microcarcinoma.

Authors: Kuai-Lu Lin; Ou-Chen Wang; Xiao-Hua Zhang; Xuan-Xuan Dai; Xiao-Qu Hu; Jin-Miao Qu
Journal: Ann Surg Oncol Date: 2010-10-15 Impact factor: 5.344

3. Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma.

Authors: Sandya Liyanarachchi; Anna Wojcicka; Wei Li; Malgorzata Czetwertynska; Elzbieta Stachlewska; Rebecca Nagy; Kevin Hoag; Bernard Wen; Rafal Ploski; Matthew D Ringel; Izabella Kozłowicz-Gudzinska; Wojciech Gierlikowski; Krystian Jazdzewski; Huiling He; Albert de la Chapelle
Journal: Thyroid Date: 2013-08-29 Impact factor: 6.568

4. Additive effect of RET polymorphisms on sporadic medullary thyroid carcinoma susceptibility and tumor aggressiveness.

Authors: Lucieli Ceolin; Débora Rodrigues Siqueira; Carla Vaz Ferreira; Mírian Romitti; Silvana Cavalcante Maia; Leonardo Leiria; Daisy Crispim; Patrícia Ashton-Prolla; Patrícia Ashton Prolla; Ana Luiza Maia
Journal: Eur J Endocrinol Date: 2012-02-17 Impact factor: 6.664

5. Integrated genomic characterization of papillary thyroid carcinoma.

Authors:
Journal: Cell Date: 2014-10-23 Impact factor: 41.582

6. Germline and somatic mutations in an oncogene: RET mutations in inherited medullary thyroid carcinoma.

Authors: D J Marsh; S D Andrew; C Eng; D L Learoyd; A G Capes; R Pojer; A L Richardson; C Houghton; L M Mulligan; B A Ponder; B G Robinson
Journal: Cancer Res Date: 1996-03-15 Impact factor: 12.701

7. RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact.

Authors: Marco Volante; Ida Rapa; Manoj Gandhi; Gianni Bussolati; Daniela Giachino; Mauro Papotti; Yuri E Nikiforov
Journal: J Clin Endocrinol Metab Date: 2009-10-16 Impact factor: 5.958

8. RET genotypes in sporadic medullary thyroid cancer: studies in a large Italian series.

Authors: Laura Fugazzola; Marina Muzza; Caterina Mian; Daniela Cordella; Susi Barollo; Luisella Alberti; Valentina Cirello; Davide Dazzi; Maria Elisa Girelli; Giuseppe Opocher; Paolo Beck-Peccoz; Luca Persani
Journal: Clin Endocrinol (Oxf) Date: 2008-02-11 Impact factor: 3.478

9. Highly recurrent TERT promoter mutations in human melanoma.

Authors: Franklin W Huang; Eran Hodis; Mary Jue Xu; Gregory V Kryukov; Lynda Chin; Levi A Garraway
Journal: Science Date: 2013-01-24 Impact factor: 47.728

10. Polymorphisms in base excision repair genes and thyroid cancer risk.

Authors: Luís S Santos; Sandra C Branco; Susana N Silva; Ana Paula Azevedo; Octávia M Gil; Isabel Manita; Teresa C Ferreira; Edward Limbert; José Rueff; Jorge F Gaspar
Journal: Oncol Rep Date: 2012-08-22 Impact factor: 3.906

2 in total

1. Downregulation of CSN6 attenuates papillary thyroid carcinoma progression by reducing Wnt/β-catenin signaling and sensitizes cancer cells to FH535 therapy.

Authors: Duo Wen; Tian Liao; Ben Ma; Ning Qu; Rong-Liang Shi; Zhong-Wu Lu; Yu-Long Wang; Wen-Jun Wei; Qing-Hai Ji
Journal: Cancer Med Date: 2018-01-17 Impact factor: 4.452

Review 2. Influencers on Thyroid Cancer Onset: Molecular Genetic Basis.

Authors: Berta Luzón-Toro; Raquel María Fernández; Leticia Villalba-Benito; Ana Torroglosa; Guillermo Antiñolo; Salud Borrego
Journal: Genes (Basel) Date: 2019-11-08 Impact factor: 4.096

2 in total