Literature DB >> 27173501

Quinine and the ABCs of Long QT: A Patient's Misfortune with Arthritis, (Alcoholic) Beverages, and Cramps.

Elyce T Sheehan1, Jarrod D Frizzell2, Jude Gabaldon3, Michael B West3.   

Abstract

A 91-year-old woman presented to the emergency department by ambulance after her family found her minimally responsive. Telemetry monitoring demonstrated episodes of non-sustained polymorphic ventricular tachycardia (PMVT) associated with significantly prolonged repolarization. Her medical history revealed that she was taking quinine or a derivative in three different forms: hydroxychloroquine, quinine sulfate (for leg cramps), and her gin mixed with tonic water (containing quinine). The present case is illustrative of classic etiologies and findings of acquired long QT syndrome, and serves as an important reminder for providers to take a complete medication history, including use of duplicative and alternative medicines and type of alcohol consumption.

Entities:  

Keywords:  cardiac arrhythmia; gin and tonic; prolonged QT; quinine

Mesh:

Substances:

Year:  2016        PMID: 27173501      PMCID: PMC5023602          DOI: 10.1007/s11606-016-3738-7

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN: 0884-8734            Impact factor:   5.128


  12 in total

1.  Risks of the consumption of beverages containing quinine.

Authors:  James Robert Brasić
Journal:  Psychol Rep       Date:  2003-12

Review 2.  Drug-induced prolongation of the QT interval.

Authors:  Dan M Roden
Journal:  N Engl J Med       Date:  2004-03-04       Impact factor: 91.245

3.  Determinants of torsades de pointes in older patients with drug-associated long QT syndrome: a case-control study.

Authors:  Sylvain Goutelle; Elodie Sidolle; Michel Ducher; Jacques Caron; Quadiri Timour; Patrice Nony; Aurore Gouraud
Journal:  Drugs Aging       Date:  2014-08       Impact factor: 3.923

Review 4.  Should people with nocturnal leg cramps drink tonic water and bitter lemon?

Authors:  J R Brasić
Journal:  Psychol Rep       Date:  1999-04

Review 5.  Quinine for muscle cramps.

Authors:  Sherif El-Tawil; Tarique Al Musa; Haseeb Valli; Michael P T Lunn; Ruth Brassington; Tariq El-Tawil; Markus Weber
Journal:  Cochrane Database Syst Rev       Date:  2015-04-05

Review 6.  Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes.

Authors:  Charles Antzelevitch
Journal:  Europace       Date:  2007-09       Impact factor: 5.214

Review 7.  Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors.

Authors:  David Zeltser; Dan Justo; Amir Halkin; Vitaly Prokhorov; Karin Heller; Sami Viskin
Journal:  Medicine (Baltimore)       Date:  2003-07       Impact factor: 1.889

Review 8.  Is quinine effective and safe in leg cramps?

Authors:  A K Mandal; T Abernathy; S N Nelluri; V Stitzel
Journal:  J Clin Pharmacol       Date:  1995-06       Impact factor: 3.126

Review 9.  Cardiotoxicity of antimalarial drugs.

Authors:  Nicholas J White
Journal:  Lancet Infect Dis       Date:  2007-08       Impact factor: 25.071

Review 10.  Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes.

Authors:  Akshay Gupta; Andrew T Lawrence; Kousik Krishnan; Clifford J Kavinsky; Richard G Trohman
Journal:  Am Heart J       Date:  2007-06       Impact factor: 4.749

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  2 in total

1.  Torsade de pointes associated with chloroquine, hydroxychloroquine, and azithromycin: a retrospective analysis of individual case safety reports from VigiBase.

Authors:  Diego Macías Saint-Gerons; Rafael Tabarés-Seisdedos
Journal:  Eur J Clin Pharmacol       Date:  2021-05-03       Impact factor: 3.064

2.  Cardiac Complications Attributed to Hydroxychloroquine: A Systematic Review of the Literature Pre-COVID-19.

Authors:  Georgi Fram; Dee D Wang; Kelly Malette; Pedro Villablanca; Guson Kang; Kent So; Mir B Basir; Arfaat Khan; John E McKinnon; Marcus Zervos; William W O'Neill
Journal:  Curr Cardiol Rev       Date:  2021
  2 in total

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