T J Yun1, H R Cho1, S H Choi2, H Kim1, J-K Won3, S-W Park4, J-H Kim1, C-H Sohn1, M H Han5. 1. From the Department of Radiology (T.J.Y., H.R.C., S.H.C., H.K., S.-W.P., J.-h.K., C.-H.S., M.H.H.), Seoul National University College of Medicine, Republic of Korea Departments of Radiology (T.J.Y., H.R.C., S.H.C., H.K., J.-h.K., C.-H.S., M.H.H.). 2. From the Department of Radiology (T.J.Y., H.R.C., S.H.C., H.K., S.-W.P., J.-h.K., C.-H.S., M.H.H.), Seoul National University College of Medicine, Republic of Korea Departments of Radiology (T.J.Y., H.R.C., S.H.C., H.K., J.-h.K., C.-H.S., M.H.H.) choiseunghong@gmail.com. 3. Pathology (J.-K.W.). 4. From the Department of Radiology (T.J.Y., H.R.C., S.H.C., H.K., S.-W.P., J.-h.K., C.-H.S., M.H.H.), Seoul National University College of Medicine, Republic of Korea Department of Radiology (S.-W.P.), Seoul National University Boramae Medical Center, Seoul, Republic of Korea. 5. From the Department of Radiology (T.J.Y., H.R.C., S.H.C., H.K., S.-W.P., J.-h.K., C.-H.S., M.H.H.), Seoul National University College of Medicine, Republic of Korea Departments of Radiology (T.J.Y., H.R.C., S.H.C., H.K., J.-h.K., C.-H.S., M.H.H.) Neurosurgery (M.H.H.), Seoul National University Hospital, Seoul, Republic of Korea.
Abstract
BACKGROUND AND PURPOSE: The usefulness of arterial spin-labeling for the evaluation of the effect of the antiangiogenic therapy has not been elucidated. Our aim was to evaluate the antiangiogenic effect of bevacizumab in a rat glioblastoma model based on arterial spin-labeling perfusion MR imaging. MATERIALS AND METHODS: DSC and arterial spin-labeling perfusion MR imaging were performed by using a 9.4T MR imaging scanner in nude rats with glioblastoma. Rats were randomly assigned to the following 3 groups: control, 3-day treatment, and 10-day treatment after bevacizumab injection. One-way analysis of variance with a post hoc test was used to compare perfusion parameters (eg, normalized CBV and normalized CBF from DSC MR imaging and normalized CBF based on arterial spin-labeling) with microvessel area on histology. The Pearson correlations between perfusion parameters and microvessel area were also determined. RESULTS: All of the normalized CBV from DSC, normalized CBF from DSC, normalized CBF from arterial spin-labeling, and microvessel area values showed significant decrease after treatment (P < .001, P < .001, P = .005, and P < .001, respectively). In addition, normalized CBV and normalized CBF from DSC and normalized CBF from arterial spin-labeling strongly correlated with microvessel area (correlation coefficient, r = 0.911, 0.869, and 0.860, respectively; P < .001 for all). CONCLUSIONS: Normalized CBF based on arterial spin-labeling and normalized CBV and normalized CBF based on DSC have the potential for evaluating the effect of antiangiogenic therapy on glioblastomas treated with bevacizumab, with a strong correlation with microvessel area.
BACKGROUND AND PURPOSE: The usefulness of arterial spin-labeling for the evaluation of the effect of the antiangiogenic therapy has not been elucidated. Our aim was to evaluate the antiangiogenic effect of bevacizumab in a ratglioblastoma model based on arterial spin-labeling perfusion MR imaging. MATERIALS AND METHODS: DSC and arterial spin-labeling perfusion MR imaging were performed by using a 9.4T MR imaging scanner in nude rats with glioblastoma. Rats were randomly assigned to the following 3 groups: control, 3-day treatment, and 10-day treatment after bevacizumab injection. One-way analysis of variance with a post hoc test was used to compare perfusion parameters (eg, normalized CBV and normalized CBF from DSC MR imaging and normalized CBF based on arterial spin-labeling) with microvessel area on histology. The Pearson correlations between perfusion parameters and microvessel area were also determined. RESULTS: All of the normalized CBV from DSC, normalized CBF from DSC, normalized CBF from arterial spin-labeling, and microvessel area values showed significant decrease after treatment (P < .001, P < .001, P = .005, and P < .001, respectively). In addition, normalized CBV and normalized CBF from DSC and normalized CBF from arterial spin-labeling strongly correlated with microvessel area (correlation coefficient, r = 0.911, 0.869, and 0.860, respectively; P < .001 for all). CONCLUSIONS: Normalized CBF based on arterial spin-labeling and normalized CBV and normalized CBF based on DSC have the potential for evaluating the effect of antiangiogenic therapy on glioblastomas treated with bevacizumab, with a strong correlation with microvessel area.
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