Ritsuko Kohno1, Haruhiko Abe1, Naoki Akamatsu2, David G Benditt3. 1. Department of Heart Rhythm Management, University of Occupational and Environmental Health, Kitakyushu, Japan. 2. Department of Neurology, International University of Health and Welfare School of Medical Sciences, Fukuoka, Japan. 3. Cardiac Arrhythmia Center, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota, USA.
Abstract
BACKGROUND: Ictal asystole (IA) is an infrequent complication of temporal lobe epilepsy (TLE), but one that may cause transient loss of consciousness (T-LOC) similar to reflex syncope (particularly the vasovagal faint). Although IA-triggered T-LOC is relatively rare, its recognition is therapeutically important. However, while the need for anti-epileptic drugs (AeDs) is broadly accepted, cardiac pacing in IA is controversial. This study aimed to evaluate the need for cardiac pacing in the follow-up of IA patients being treated with AeDs. METHODS AND RESULTS: Six patients (2 men, mean age of 66 ± 16 years), with documented prolonged asystole on electrocardiogram (ECG) in association with TLE, were followed for an average of 19.7 (range, 2-37) years; a pacemaker had been implanted in 4 of 6 patients, whereas 2 patients underwent long-term ECG monitoring with an implantable loop recorder (ILR). The longest documented IA pause lasted 12.6 ± 6.2 (range: 3.5-20) seconds. All patients were treated with AeDs. During follow-up, after optimization of AeD dosing, none of the patients had T-LOC spells or detected epileptic seizure episodes. During regular device interrogation, there was no evidence of pacing interventions (cumulative ventricular pacing, 0%) in the 4 pacemaker patients, and no symptomatic bradyarrhythmias in the 2 ILR patients. CONCLUSIONS: AeD therapy was effective to prevent IA in this cohort of TLE patients with prior IA. Consequently, pacemaker implantation is not immediately indicated for IA prevention, but should be reserved for those cases in which there is documented failure of AeD therapy.
BACKGROUND:Ictal asystole (IA) is an infrequent complication of temporal lobe epilepsy (TLE), but one that may cause transient loss of consciousness (T-LOC) similar to reflex syncope (particularly the vasovagal faint). Although IA-triggered T-LOC is relatively rare, its recognition is therapeutically important. However, while the need for anti-epileptic drugs (AeDs) is broadly accepted, cardiac pacing in IA is controversial. This study aimed to evaluate the need for cardiac pacing in the follow-up of IA patients being treated with AeDs. METHODS AND RESULTS: Six patients (2 men, mean age of 66 ± 16 years), with documented prolonged asystole on electrocardiogram (ECG) in association with TLE, were followed for an average of 19.7 (range, 2-37) years; a pacemaker had been implanted in 4 of 6 patients, whereas 2 patients underwent long-term ECG monitoring with an implantable loop recorder (ILR). The longest documented IA pause lasted 12.6 ± 6.2 (range: 3.5-20) seconds. All patients were treated with AeDs. During follow-up, after optimization of AeD dosing, none of the patients had T-LOC spells or detected epilepticseizure episodes. During regular device interrogation, there was no evidence of pacing interventions (cumulative ventricular pacing, 0%) in the 4 pacemaker patients, and no symptomatic bradyarrhythmias in the 2 ILR patients. CONCLUSIONS: AeD therapy was effective to prevent IA in this cohort of TLEpatients with prior IA. Consequently, pacemaker implantation is not immediately indicated for IA prevention, but should be reserved for those cases in which there is documented failure of AeD therapy.
Authors: Christoph Baumgartner; Johannes Koren; Martha Britto-Arias; Simone Schmidt; Susanne Pirker Journal: Clin Auton Res Date: 2019-02-25 Impact factor: 4.435
Authors: Stephanie Ballendine; Izn Shahab; Mitzel Perez-Careta; Francisco J Taveras-Almonte; Iris E Martínez-Juárez; Laura E Hernández-Vanegas; Chelsea Dolinsky; Adam Wu; Jose Francisco Tellez-Zenteno Journal: Epilepsy Behav Rep Date: 2019-07-30
Authors: Mohamed Khalil; Arif Ali Shukralla; Ronan Kilbride; Gerrard Mullins; Peter Widdess-Walsh; Norman Delanty; Hany El-Naggar Journal: Epilepsy Behav Rep Date: 2020-12-30
Authors: Anouk van Westrhenen; Sharon Shmuely; Rainer Surges; Beate Diehl; Daniel Friedman; Frans S S Leijten; Jorien van Hoey Smith; David G Benditt; J Gert van Dijk; Roland D Thijs Journal: J Cardiovasc Electrophysiol Date: 2021-09-19 Impact factor: 2.942