BACKGROUND: The long-term cardiovascular outcomes of pulmonary hypertension (PH) in preterm infants with bronchopulmonary dysplasia (BPD) are uncertain. OBJECTIVES: The purpose of this study was to assess outcomes of PH in prematurely born children diagnosed with moderate to severe BPD. METHODS: We retrospectively reviewed the medical records of patients born before 32 weeks of gestation and diagnosed with moderate to severe BPD from June 2004 to April 2008. Patients were recruited for a cross-sectional study from August to October 2014 and underwent echocardiography. RESULTS: Forty-two children were enrolled. Their mean gestational age and birth weight were 26.2 ± 1.7 weeks and 753.1 ± 172.5 g, respectively. Sixteen patients (38%) were diagnosed with PH at a mean age of 3.3 ± 1.6 months, and the PH improved after a median of 12.3 months (range 0.7-46.6). Cardiovascular function was reassessed at a mean age of 7.7 ± 0.9 years, at which time 1 patient was taking a medication for recurrent PH, and 12 (28.6%) patients exhibited elevated blood pressure. Conventional 2-dimensional and Doppler echocardiography indicated normal ventricular function in all children. However, right ventricular longitudinal strains were decreased in children with previous PH. CONCLUSIONS: Subclinical ventricular dysfunction was detectable using sensitive echocardiographic techniques in children with previous BPD-associated PH. Long-term follow-up and meticulous cardiovascular function assessment are required in this population.
BACKGROUND: The long-term cardiovascular outcomes of pulmonary hypertension (PH) in preterm infants with bronchopulmonary dysplasia (BPD) are uncertain. OBJECTIVES: The purpose of this study was to assess outcomes of PH in prematurely born children diagnosed with moderate to severe BPD. METHODS: We retrospectively reviewed the medical records of patients born before 32 weeks of gestation and diagnosed with moderate to severe BPD from June 2004 to April 2008. Patients were recruited for a cross-sectional study from August to October 2014 and underwent echocardiography. RESULTS: Forty-two children were enrolled. Their mean gestational age and birth weight were 26.2 ± 1.7 weeks and 753.1 ± 172.5 g, respectively. Sixteen patients (38%) were diagnosed with PH at a mean age of 3.3 ± 1.6 months, and the PH improved after a median of 12.3 months (range 0.7-46.6). Cardiovascular function was reassessed at a mean age of 7.7 ± 0.9 years, at which time 1 patient was taking a medication for recurrent PH, and 12 (28.6%) patients exhibited elevated blood pressure. Conventional 2-dimensional and Doppler echocardiography indicated normal ventricular function in all children. However, right ventricular longitudinal strains were decreased in children with previous PH. CONCLUSIONS: Subclinical ventricular dysfunction was detectable using sensitive echocardiographic techniques in children with previous BPD-associated PH. Long-term follow-up and meticulous cardiovascular function assessment are required in this population.
Authors: L B DeVries; R J Heyne; C Ramaciotti; L S Brown; M A Jaleel; V S Kapadia; P J Burchfield; L P Brion Journal: J Perinatol Date: 2017-06-15 Impact factor: 2.521
Authors: Aisling Smith; Jyothsna R Purna; Michael P Castaldo; Daniel Ibarra-Rios; Regan E Giesinger; Danielle R Rios; Dany E Weisz; Amish Jain; Afif F El-Khuffash; Patrick J McNamara Journal: Echocardiography Date: 2019-06-27 Impact factor: 1.724
Authors: Collin T Erickson; Meghna D Patel; Swati Choudhry; Karl Stessy Bisselou; Tim Sekarski; Mary Craft; Ling Li; Afif El Khuffash; Aaron Hamvas; Shelby Kutty; Gautam K Singh; Philip T Levy Journal: Cardiol Young Date: 2019-07-09 Impact factor: 1.093
Authors: Dandan Zhu; Jean Tan; Amina S Maleken; Ruth Muljadi; Siow T Chan; Sin N Lau; Kirstin Elgass; Bryan Leaw; Joanne Mockler; Daniel Chambers; Kristen T Leeman; Carla F Kim; Euan M Wallace; Rebecca Lim Journal: Stem Cell Res Ther Date: 2017-11-10 Impact factor: 6.832