João Soeiro Teodoro1,2, Rui Silva2, Ana Teresa Varela1,2, Filipe Valente Duarte1,2, Anabela Pinto Rolo1,2, Saber Hussain3, Carlos Marques Palmeira1,2. 1. Center for Neurosciences & Cell Biology of the University of Coimbra, Coimbra, Portugal. 2. Department of Life Sciences of the Faculty of Sciences & Technology of the University of Coimbra, Coimbra, Portugal. 3. 711th HPW/RHDJ, Molecular Bioeffects Branch, Bioeffects Division, Human Effectiveness Directorate, Air Force Research Laboratory, Wright Patterson AFB, Dayton, OH 45433, USA.
Abstract
AIM: Nanoparticles (NPs) have increasingly been studied due to their probable harmful effects to both humans and the environment. However, despite several indications of possible harmful effects, no long-term studies using a low dose of silver nanoparticles (AgNP) have been conducted in vivo. RESULTS: Our data demonstrate that the prolonged exposure to a very low dose of AgNP was sufficient to cause alterations in hepatic mitochondrial function. Mitochondrial function compromised by AgNPs is recovered by pretreatment with the antioxidant N-acetylcysteine, which highlights the crucial role of oxidative stress in AgNPs' toxicity. CONCLUSION: Our data show for the first time that even a very low dose of AgNP can cause harmful effects on mitochondrial function, thus compromising the normal function of the organ.
AIM: Nanoparticles (NPs) have increasingly been studied due to their probable harmful effects to both humans and the environment. However, despite several indications of possible harmful effects, no long-term studies using a low dose of silver nanoparticles (AgNP) have been conducted in vivo. RESULTS: Our data demonstrate that the prolonged exposure to a very low dose of AgNP was sufficient to cause alterations in hepatic mitochondrial function. Mitochondrial function compromised by AgNPs is recovered by pretreatment with the antioxidant N-acetylcysteine, which highlights the crucial role of oxidative stress in AgNPs' toxicity. CONCLUSION: Our data show for the first time that even a very low dose of AgNP can cause harmful effects on mitochondrial function, thus compromising the normal function of the organ.
Authors: Julian Bejarano; Mario Navarro-Marquez; Francisco Morales-Zavala; Javier O Morales; Ivonne Garcia-Carvajal; Eyleen Araya-Fuentes; Yvo Flores; Hugo E Verdejo; Pablo F Castro; Sergio Lavandero; Marcelo J Kogan Journal: Theranostics Date: 2018-09-09 Impact factor: 11.556