Carlos Menezes1, Rui Carvalho1, Joana Neves-Martins2, Carla Teixeira1. 1. Department of Ophthalmology, Hospital Pedro Hispano, Matosinhos, Portugal. 2. Department of Ophthalmology, Hospital Pedro Hispano, Matosinhos, Portugal; Clínica Oftalmológica Dr. Neves Martins, Porto, Portugal; Hospital Privado da Trofa, Trofa, Portugal.
Abstract
BACKGROUND/AIMS: The aim of our study was to report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) with a markedly asymmetric presentation and fundoscopic response to palliative chemotherapy. CASE REPORT: We report a 67-year-old Caucasian man who presented with vision loss in his right eye. The best-corrected visual acuities were 2/10 in the right eye and 10/10 in the left eye, and biomicroscopy revealed bilateral mild cataracts. Fundoscopy of the right eye showed a macular flat and pigmented lesion extending beyond the posterior pole with areas of giraffe-type pigmentation and an overlying exudative retinal detachment. Nothing remarkable was detected in the left eye apart from a small round hypopigmented area of retinal pigment epithelium atrophy in the papillomacular bundle. BDUMP was diagnosed, and the workup for systemic malignancy revealed a pulmonary adenocarcinoma. After chemotherapy, not only did the right eye's visual acuity improve and the serous detachment resolve, but also the pigmentation decreased. CONCLUSION: BDUMP presentation can be markedly asymmetric and resemble a giant unilateral choroidal nevus. Response to chemotherapy was unique not only for the usual retinal detachment resolution, but also because of an evident regression of pigmentation.
BACKGROUND/AIMS: The aim of our study was to report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) with a markedly asymmetric presentation and fundoscopic response to palliative chemotherapy. CASE REPORT: We report a 67-year-old Caucasian man who presented with vision loss in his right eye. The best-corrected visual acuities were 2/10 in the right eye and 10/10 in the left eye, and biomicroscopy revealed bilateral mild cataracts. Fundoscopy of the right eye showed a macular flat and pigmented lesion extending beyond the posterior pole with areas of giraffe-type pigmentation and an overlying exudative retinal detachment. Nothing remarkable was detected in the left eye apart from a small round hypopigmented area of retinal pigment epithelium atrophy in the papillomacular bundle. BDUMP was diagnosed, and the workup for systemic malignancy revealed a pulmonary adenocarcinoma. After chemotherapy, not only did the right eye's visual acuity improve and the serous detachment resolve, but also the pigmentation decreased. CONCLUSION:BDUMP presentation can be markedly asymmetric and resemble a giant unilateral choroidal nevus. Response to chemotherapy was unique not only for the usual retinal detachment resolution, but also because of an evident regression of pigmentation.
Authors: Eduardo V Navajas; E Rand Simpson; Hatem Krema; Dena S Hammoudi; Daniel Weisbrod; Marcus Bernardini; Filiberto Altomare Journal: Ophthalmic Surg Lasers Imaging Date: 2011-10-27
Authors: J S Pulido; T J Flotte; H Raja; S Miles; J L Winters; R Niles; E A Jaben; S N Markovic; J Davies; K R Kalli; R G Vile; J J Garcia; D R Salomao Journal: Eye (Lond) Date: 2013-06-21 Impact factor: 3.775