Literature DB >> 27171437

Identification of Individual Exosome-Like Vesicles by Surface Enhanced Raman Spectroscopy.

Stephan Stremersch1, Monica Marro2, Bat-El Pinchasik3, Pieter Baatsen4, An Hendrix5, Stefaan C De Smedt1, Pablo Loza-Alvarez2, Andre G Skirtach3,6,7, Koen Raemdonck1, Kevin Braeckmans7,8.   

Abstract

Exosome-like vesicles (ELVs) are a novel class of biomarkers that are receiving a lot of attention for the detection of cancer at an early stage. In this study the feasibility of using a surface enhanced Raman spectroscopy (SERS) based method to distinguish between ELVs derived from different cellular origins is evaluated. A gold nanoparticle based shell is deposited on the surface of ELVs derived from cancerous and healthy cells, which enhances the Raman signal while maintaining a colloidal suspension of individual vesicles. This nanocoating allows the recording of SERS spectra from single vesicles. By using partial least squares discriminant analysis on the obtained spectra, vesicles from different origin can be distinguished, even when present in the same mixture. This proof-of-concept study paves the way for noninvasive (cancer) diagnostic tools based on exosomal SERS fingerprinting in combination with multivariate statistical analysis.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  diagnostics; exosome-like vesicles; gold nanoparticles; multivariate statistical analysis; surface enhanced Raman spectroscopy

Mesh：

Substances：

Year:  2016        PMID： 27171437     DOI： 10.1002/smll.201600393

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  45 in total

Review 1.  Microfluidic approaches for isolation, detection, and characterization of extracellular vesicles: Current status and future directions.

Authors:  Shima Gholizadeh; Mohamed Shehata Draz; Maryam Zarghooni; Amir Sanati-Nezhad; Saeid Ghavami; Hadi Shafiee; Mohsen Akbari
Journal:  Biosens Bioelectron       Date:  2016-12-30       Impact factor: 10.618

Review 2.  Recent Advances in the Label-Free Characterization of Exosomes for Cancer Liquid Biopsy: From Scattering and Spectroscopy to Nanoindentation and Nanodevices.

Authors:  Riccardo Di Santo; Sabrina Romanò; Alberto Mazzini; Svetlana Jovanović; Giuseppina Nocca; Gaetano Campi; Massimiliano Papi; Marco De Spirito; Flavio Di Giacinto; Gabriele Ciasca
Journal:  Nanomaterials (Basel)       Date:  2021-06-02       Impact factor: 5.076

3.  Optical clearing agent increases effectiveness of photodynamic therapy in a mouse model of cutaneous melanoma: an analysis by Raman microspectroscopy.

Authors:  Letícia Palombo Martinelli; Ievgeniia Iermak; Lilian Tan Moriyama; Michelle Barreto Requena; Layla Pires; Cristina Kurachi
Journal:  Biomed Opt Express       Date:  2020-10-19       Impact factor: 3.732

4.  Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer.

Authors:  Joseph Carmicheal; Chihiro Hayashi; Xi Huang; Lei Liu; Yao Lu; Alexey Krasnoslobodtsev; Alexander Lushnikov; Prakash G Kshirsagar; Asish Patel; Maneesh Jain; Yuri L Lyubchenko; Yongfeng Lu; Surinder K Batra; Sukhwinder Kaur
Journal:  Nanomedicine       Date:  2018-12-11       Impact factor: 5.307

5.  Rapid Enrichment and Detection of Extracellular Vesicles Enabled by CuS-Enclosed Microgels.

Authors:  Qiaoshi Jiang; Yang Liu; Linlin Wang; Gary Brent Adkins; Wenwan Zhong
Journal:  Anal Chem       Date:  2019-12-05       Impact factor: 6.986

6.  Present and Future of Surface-Enhanced Raman Scattering.

Authors:  Judith Langer; Dorleta Jimenez de Aberasturi; Javier Aizpurua; Ramon A Alvarez-Puebla; Baptiste Auguié; Jeremy J Baumberg; Guillermo C Bazan; Steven E J Bell; Anja Boisen; Alexandre G Brolo; Jaebum Choo; Dana Cialla-May; Volker Deckert; Laura Fabris; Karen Faulds; F Javier García de Abajo; Royston Goodacre; Duncan Graham; Amanda J Haes; Christy L Haynes; Christian Huck; Tamitake Itoh; Mikael Käll; Janina Kneipp; Nicholas A Kotov; Hua Kuang; Eric C Le Ru; Hiang Kwee Lee; Jian-Feng Li; Xing Yi Ling; Stefan A Maier; Thomas Mayerhöfer; Martin Moskovits; Kei Murakoshi; Jwa-Min Nam; Shuming Nie; Yukihiro Ozaki; Isabel Pastoriza-Santos; Jorge Perez-Juste; Juergen Popp; Annemarie Pucci; Stephanie Reich; Bin Ren; George C Schatz; Timur Shegai; Sebastian Schlücker; Li-Lin Tay; K George Thomas; Zhong-Qun Tian; Richard P Van Duyne; Tuan Vo-Dinh; Yue Wang; Katherine A Willets; Chuanlai Xu; Hongxing Xu; Yikai Xu; Yuko S Yamamoto; Bing Zhao; Luis M Liz-Marzán
Journal:  ACS Nano       Date:  2019-10-08       Impact factor: 15.881

7.  Characterization of extracellular vesicles derived from mesenchymal stromal cells by surface-enhanced raman spectroscopy.

Authors:  Nina M Ćulum; Tyler T Cooper; Gillian I Bell; David A Hess; François Lagugné-Labarthet
Journal:  Anal Bioanal Chem       Date:  2021-06-17       Impact factor: 4.142

Review 8.  Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles.

Authors:  Guillermo Bordanaba-Florit; Félix Royo; Sergei G Kruglik; Juan M Falcón-Pérez
Journal:  Nat Protoc       Date:  2021-06-16       Impact factor: 13.491

Review 9.  Emerging methods in biomarker identification for extracellular vesicle-based liquid biopsy.

Authors:  Yaxuan Liang; Brandon M Lehrich; Siyang Zheng; Mengrou Lu
Journal:  J Extracell Vesicles       Date:  2021-05-12

10.  Surface-Enhanced Raman Spectroscopy to Characterize Different Fractions of Extracellular Vesicles from Control and Prostate Cancer Patients.

Authors:  Eric Boateng Osei; Liliia Paniushkina; Konrad Wilhelm; Jürgen Popp; Irina Nazarenko; Christoph Krafft
Journal:  Biomedicines       Date:  2021-05-20
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