| Literature DB >> 27170368 |
Rebecca L Hurst1, Clifton L Gooch2,3.
Abstract
Autoimmune myasthenia gravis (MG) is the prototypic, antibody-mediated neuromuscular disease and is characterized by a decrease in the number of functional acetylcholine receptors (AChR) within the muscle end plate zone of the neuromuscular junction (NMJ). Although the pathophysiology of AChR-mediated myasthenia gravis has been extensively studied over the last 40 years since its original description by Patrick and Lindstrom (Science 180:871-872, 1973), less is known about the much more recently described muscle-specific kinase (MuSK) antibody-mediated MG. MuSK-MG has features clinically distinct from Ach-R MG, as well as a different pattern of response to treatment and a unique immunopathogenesis.Entities:
Keywords: Acetylcholine receptor antibody; Muscle-specific receptor tyrosine kinase; Myasthenia gravis; Neuromuscular junction
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Year: 2016 PMID： 27170368 DOI： 10.1007/s11910-016-0668-z
Source DB: PubMed Journal: Curr Neurol Neurosci Rep ISSN： 1528-4042 Impact factor: 5.081