Fabrice Bruneel1, Florence Tubach2,3,4, Jean-Paul Mira5, Sandrine Houze6, Sebastien Gibot7, Marie-Genevieve Huisse8, Bruno Megarbane9, Christophe Choquet10, Philippe Corne11, Eric Peytel12, Daniel Villers13, Christophe Camus14, Olivier Bouchaud15, Eric Caumes16, Pierre-Marie Girard17, Fabrice Simon18, Antoine Kalloumeh19, Carine Roy3,4, Remy Durand20, Jacques Le Bras6, Sophie Matheron21, Michel Wolff22. 1. Service de Réanimation Médico-Chirurgicale, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157, Le Chesnay, France. fbruneel@ch-versailles.fr. 2. Université Paris Diderot, Sorbonne Paris Cité, UMR 1123, 75018, Paris, France. 3. Département d'Epidémiologie et Recherche Clinique, CIC-EC 1425, AP-HP, Hôpital Bichat, 75018, Paris, France. 4. INSERM, CIC-EC 1425, U1123, 75018, Paris, France. 5. Service de Réanimation, Centre Hospitalier Universitaire Cochin Saint-Vincent de Paul, AP-HP, 75014, Paris, France. 6. Service de Parasitologie, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, 75018, Paris, France. 7. Service de Réanimation Médicale, Hôpital Central, Centre Hospitalier Universitaire de Nancy, 54035, Nancy, France. 8. Unité d'Hémato-Immunologie, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, 75018, Paris, France. 9. Service de Réanimation Médicale et Toxicologique, Centre Hospitalier Universitaire Lariboisière, AP-HP, 75010, Paris, France. 10. Service d'Accueil des Urgences, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, 75018, Paris, France. 11. Service de Réanimation Médicale, Centre Hospitalier Universitaire Gui de Chauliac, 34295, Montpellier, France. 12. Service d'Anesthésiologie et Réanimation, Hôpital d'Instruction des Armées Laveran, 13384, Marseille, France. 13. Service de Réanimation Médicale Polyvalente, Centre Hospitalier Universitaire de Nantes, Hotel Dieu, 44093, Nantes, France. 14. Service de Réanimation Médicale et Infectieuse, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 35033, Rennes, France. 15. Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Avicenne, AP-HP, 93009, Bobigny, France. 16. Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de la Pitié-Salpêtrière, AP-HP, 75013, Paris, France. 17. Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Saint- Antoine, AP-HP, 75012, Paris, France. 18. Service de Maladies Infectieuses et Tropicales, Hôpital d'Instruction des Armées Laveran, 13384, Marseille, France. 19. Unité de Biochimie Clinique, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, 75018, Paris, France. 20. Service de Parasitologie, Centre Hospitalier Universitaire Avicenne, AP-HP, 93009, Bobigny, France. 21. Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, 75018, Paris, France. 22. Service de Réanimation Médicale et Infectieuse, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, 75018, Paris, France.
Abstract
PURPOSE: Prospective data on potential factors associated with severity of imported Plasmodium falciparum malaria are lacking. We evaluated whether several host- and parasite-related biomarkers may improve early severity evaluation. METHODS: Prospective multicenter observational study comparing uncomplicated and severe imported falciparum malaria in adults conducted in France in 52 units, from 2007 to 2010. Association of several host- and parasite-related biomarkers with severity of malaria was tested using univariate and multivariate analyses. RESULTS: Of 295 patients, 140 had uncomplicated malaria and 155 severe malaria (including very severe and less severe cases according to predefined criteria). Curative intravenous quinine treatment was used in 154/155 patients with severe malaria and atovaquone/proguanil in 74 % of patients with uncomplicated malaria. Hospital mortality was 5.2 % (8 patients), all in the severe malaria group. Among host-related biomarkers, CRP, procalcitonin, and sTREM-1 were significantly higher and albumin was significantly lower in severe versus uncomplicated malaria; only the last three biomarkers also differed significantly between the very and less severe malaria groups. Among parasite-related biomarkers, only plasma PfHRP2 was significantly higher in severe versus uncomplicated malaria and in very severe versus less severe malaria; parasitemia did not differ between very and less severe malaria. By multivariate analysis, only lower plasma albumin and higher sTREM-1 were associated with greater severity, with intermediate accuracies. CONCLUSIONS: During imported malaria, the most useful biomarkers associated with severity seem to be plasma albumin and sTREM-1; and among parasite-related parameters, PfHRP2 was more strongly associated with severity than parasitemia was.
PURPOSE: Prospective data on potential factors associated with severity of imported Plasmodium falciparum malaria are lacking. We evaluated whether several host- and parasite-related biomarkers may improve early severity evaluation. METHODS: Prospective multicenter observational study comparing uncomplicated and severe imported falciparum malaria in adults conducted in France in 52 units, from 2007 to 2010. Association of several host- and parasite-related biomarkers with severity of malaria was tested using univariate and multivariate analyses. RESULTS: Of 295 patients, 140 had uncomplicated malaria and 155 severe malaria (including very severe and less severe cases according to predefined criteria). Curative intravenous quinine treatment was used in 154/155 patients with severe malaria and atovaquone/proguanil in 74 % of patients with uncomplicated malaria. Hospital mortality was 5.2 % (8 patients), all in the severe malaria group. Among host-related biomarkers, CRP, procalcitonin, and sTREM-1 were significantly higher and albumin was significantly lower in severe versus uncomplicated malaria; only the last three biomarkers also differed significantly between the very and less severe malaria groups. Among parasite-related biomarkers, only plasma PfHRP2 was significantly higher in severe versus uncomplicated malaria and in very severe versus less severe malaria; parasitemia did not differ between very and less severe malaria. By multivariate analysis, only lower plasma albumin and higher sTREM-1 were associated with greater severity, with intermediate accuracies. CONCLUSIONS: During imported malaria, the most useful biomarkers associated with severity seem to be plasma albumin and sTREM-1; and among parasite-related parameters, PfHRP2 was more strongly associated with severity than parasitemia was.
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