Qunying Liu1,2, Fengyu Gao3, Xiangrong Liu4, Jing Li5, Yan Wang2, Jun Han2, Xietong Wang6. 1. Department of Obstetric and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, Shandong, China. 2. Department of Obstetrics, Eighth People's Hospital of Qingdao, Qingdao, 266100, Shandong, China. 3. Department of Gastroenterology, Qingdao Hiser Medical Group, Qingdao, 266033, Shandong, China. 4. Department of Internal Medicine, Qingdao Women and Children Hospital, Qingdao, 266000, Shandong, China. 5. Department of Obstetric and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China. 6. Department of Obstetric and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, 250021, Shandong, China. xietongwangqingdao@126.com.
Abstract
PURPOSE: Limited studies have reported the effect of prenatal alcohol exposure (PAE) on fetal liver development or liver dysfunction. The current review was conducted to systematically review published studies of PAE and liver dysfunction. METHODS: Pub Med, Embase and Web of Science database were searched using terms of "prenatal alcohol exposure" and "liver" or "fetal alcohol spectrum disease" and "liver". The pooled effect size of alcohol exposure was assessed by Hedges's g and 95 % confidence interval (CI) using fixed model or random model depending on the heterogeneity determined by Q test and I (2) statistic. RESULTS: A total of 23 studies were included. The results indicated that gestation alcohol exposure resulted in significant reduction of fetal body weight (Hedges's g = -6.854 ± 1.149, 95 % CI -9.106 to -4.602, P < 0.001), but not fetal liver weight reduction (Hedges's g = -0.076 ± 0.878, 95 % CI -1.799 to 1.647, P = 0.931). PAE resulted in significant decline in protein synthesis or enzyme activity of offspring fetal liver including glutathione and 25(OH)2D (Hedges's g = -1.149 ± 0.108, 95 % CI -1.361 to -0.938, P < 0.001), as well as significant increase in proteins including oxidants and collagen (Hedges's g = 1.330 ± 0.146, 95 % CI 1.044-1.616, P < 0.001). CONCLUSION: These results suggested that PAE affects fetal body weight but not liver weight, and that PAE may result in offspring fetal liver dysfunction.
PURPOSE: Limited studies have reported the effect of prenatal alcohol exposure (PAE) on fetal liver development or liver dysfunction. The current review was conducted to systematically review published studies of PAE and liver dysfunction. METHODS: Pub Med, Embase and Web of Science database were searched using terms of "prenatal alcohol exposure" and "liver" or "fetal alcohol spectrum disease" and "liver". The pooled effect size of alcohol exposure was assessed by Hedges's g and 95 % confidence interval (CI) using fixed model or random model depending on the heterogeneity determined by Q test and I (2) statistic. RESULTS: A total of 23 studies were included. The results indicated that gestation alcohol exposure resulted in significant reduction of fetal body weight (Hedges's g = -6.854 ± 1.149, 95 % CI -9.106 to -4.602, P < 0.001), but not fetal liver weight reduction (Hedges's g = -0.076 ± 0.878, 95 % CI -1.799 to 1.647, P = 0.931). PAE resulted in significant decline in protein synthesis or enzyme activity of offspring fetal liver including glutathione and 25(OH)2D (Hedges's g = -1.149 ± 0.108, 95 % CI -1.361 to -0.938, P < 0.001), as well as significant increase in proteins including oxidants and collagen (Hedges's g = 1.330 ± 0.146, 95 % CI 1.044-1.616, P < 0.001). CONCLUSION: These results suggested that PAE affects fetal body weight but not liver weight, and that PAE may result in offspring fetal liver dysfunction.
Authors: Mauricio Diaz-Munoz; Ericka Alejandra DE Los Rios-Arellano; Jose A Cruz-Ramos; Mariela Camacho-Barron; Dalia Luna-Moreno; Miriam Aracely Anaya-Loyola; Felipe Santoyo-Telles; Monica Navarro-Meza Journal: In Vivo Date: 2022 Sep-Oct Impact factor: 2.406
Authors: Siara K Rouzer; Jesse M Cole; Julia M Johnson; Elena I Varlinskaya; Marvin R Diaz Journal: Front Behav Neurosci Date: 2017-09-29 Impact factor: 3.558