Literature DB >> 27168172

Tunable DNA cleavage activity promoted by copper(ii) ternary complexes with N-donor heterocyclic ligands.

T Bortolotto1, P P Silva-Caldeira, C T Pich, E C Pereira-Maia, H Terenzi.   

Abstract

Several small molecules have the capacity to cleave DNA promptly at high yields, even under mild conditions. Usually, this activity has no constraints, occurring without external or user control. Here, we demonstrate that UV-light exposure can greatly enhance the DNA cleavage activity promoted by four ternary copper(ii) complexes. A remarkable photocontrolled activity was achieved, which may be interesting for chemical and biochemical applications.

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Year:  2016        PMID: 27168172     DOI: 10.1039/c6cc03142k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  4 in total

1.  New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents.

Authors:  Ariane C C de Melo; Jaime M S V P Santana; Kelen J R C Nunes; Bernardo L Rodrigues; Nathalia Castilho; Philipe Gabriel; Adolfo H Moraes; Mayra de A Marques; Guilherme A P de Oliveira; Ívina P de Souza; Hernán Terenzi; Elene C Pereira-Maia
Journal:  Molecules       Date:  2019-06-07       Impact factor: 4.411

2.  Selenylated-oxadiazoles as promising DNA intercalators: Synthesis, electronic structure, DNA interaction and cleavage.

Authors:  Jamal Rafique; Giliandro Farias; Sumbal Saba; Eduardo Zapp; Ismael Casagrande Bellettini; Cristian Andrey Momoli Salla; Ivan Helmuth Bechtold; Marcos Roberto Scheide; José Sebastião Santos Neto; David Monteiro de Souza Junior; Hugo de Campos Braga; Luiz Fernando Belchior Ribeiro; Francine Gastaldon; Claus Tröger Pich; Tiago Elias Allievi Frizon
Journal:  Dyes Pigm       Date:  2020-05-07       Impact factor: 4.889

3.  A selective CuII complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells.

Authors:  Pedro Henrique Alves Machado; Drielly Aparecida Paixão; Ricardo Campos Lino; Tiago Rodrigues de Souza; Nayara Júnia de Souza Bontempo; Luana Munique Sousa; Fernanda Van Petten de Vasconcelos Azevedo; Priscila Capelari Orsolin; Paula Marynella Alves Pereira Lima; Isabella Castro Martins; Joyce Ferreira da Costa Guerra; Samuel Cota Teixeira; Thaise Gonçalves Araújo; Luiz Ricardo Goulart; Sandra Morelli; Wendell Guerra; Robson José de Oliveira Júnior
Journal:  Sci Rep       Date:  2021-12-27       Impact factor: 4.379

4.  Peroxoniobium inhibits leukemia cell growth.

Authors:  Elene C Pereira-Maia; Ivina P Souza; Kelen J R C Nunes; Alexandre A Castro; Teodorico C Ramalho; Fernando Steffler; Helio A Duarte; Ana Pacheli; Poliana Chagas; Luiz C A Oliveira
Journal:  RSC Adv       Date:  2018-03-14       Impact factor: 3.361

  4 in total

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