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Literature DB >> 27167848

Molecular networks underlying myofibroblast fate and fibrosis.

April Stempien-Otero¹, Deok-Ho Kim², Jennifer Davis³.

Abstract

Fibrotic remodeling is a hallmark of most forms of cardiovascular disease and a strong prognostic indicator of the advancement towards heart failure. Myofibroblasts, which are a heterogeneous cell-type specialized for extracellular matrix (ECM) secretion and tissue contraction, are the primary effectors of the heart's fibrotic response. This review is focused on defining myofibroblast physiology, its progenitor cell populations, and the core signaling network that orchestrates myofibroblast differentiation as a way of understanding the basic determinants of fibrotic disease in the heart and other tissues.

Entities: CellLine Chemical Disease Gene Species

Keywords: Actin cytoskeleton; Differentiation; Fibrosis; Mitogen activated protein kinases; Myofibroblast; RNA binding proteins; TGFβ; TRP channels

Mesh：

Substances：
Biomarkers

Year: 2016 PMID： 27167848 PMCID： PMC5482716 DOI： 10.1016/j.yjmcc.2016.05.002

Source DB: PubMed Journal: J Mol Cell Cardiol ISSN： 0022-2828 Impact factor: 5.000

123 in total

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Authors: D Kessler; S Dethlefsen; I Haase; M Plomann; F Hirche; T Krieg; B Eckes
Journal: J Biol Chem Date: 2001-07-23 Impact factor: 5.157

Review 2. Myofibroblasts and mechano-regulation of connective tissue remodelling.

Authors: James J Tomasek; Giulio Gabbiani; Boris Hinz; Christine Chaponnier; Robert A Brown
Journal: Nat Rev Mol Cell Biol Date: 2002-05 Impact factor: 94.444

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Journal: Oncogene Date: 2013-02-25 Impact factor: 9.867

4. Smooth muscle actin determines mechanical force-induced p38 activation.

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Journal: J Biol Chem Date: 2004-12-09 Impact factor: 5.157

5. Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy.

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Journal: EMBO J Date: 2000-09-01 Impact factor: 11.598

Review 6. The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation.

Authors: Eric M Small
Journal: J Cardiovasc Transl Res Date: 2012-08-17 Impact factor: 4.132

7. Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.

Authors: Xiangwei Huang; Naiheng Yang; Vincent F Fiore; Thomas H Barker; Yi Sun; Stephan W Morris; Qiang Ding; Victor J Thannickal; Yong Zhou
Journal: Am J Respir Cell Mol Biol Date: 2012-03-29 Impact factor: 6.914

Review 8. Origins of cardiac fibroblasts.

Authors: Elisabeth M Zeisberg; Raghu Kalluri
Journal: Circ Res Date: 2010-11-26 Impact factor: 17.367

9. Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.

Authors: Eric T Wang; Neal A L Cody; Sonali Jog; Michela Biancolella; Thomas T Wang; Daniel J Treacy; Shujun Luo; Gary P Schroth; David E Housman; Sita Reddy; Eric Lécuyer; Christopher B Burge
Journal: Cell Date: 2012-08-17 Impact factor: 41.582

Review 10. Targeting the TGFβ signalling pathway in disease.

Authors: Rosemary J Akhurst; Akiko Hata
Journal: Nat Rev Drug Discov Date: 2012-09-24 Impact factor: 84.694

57 in total

Review 1. Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT).

Authors: A S Martínez-Ramírez; M Díaz-Muñoz; A Butanda-Ochoa; F G Vázquez-Cuevas
Journal: Purinergic Signal Date: 2016-11-29 Impact factor: 3.765

2. Myofibroblast-Specific TGFβ Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy.

Authors: Qinghang Meng; Bidur Bhandary; Md Shenuarin Bhuiyan; Jeanne James; Hanna Osinska; Iñigo Valiente-Alandi; Kritton Shay-Winkler; James Gulick; Jeffery D Molkentin; Burns C Blaxall; Jeffrey Robbins
Journal: Circ Res Date: 2018-12-07 Impact factor: 17.367

3. Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals.

Authors: Darrian Bugg; Ross Bretherton; Peter Kim; Emily Olszewski; Abigail Nagle; Austin E Schumacher; Nick Chu; Jagadambika Gunaje; Cole A DeForest; Kelly Stevens; Deok-Ho Kim; Jennifer Davis
Journal: Circ Res Date: 2020-09-04 Impact factor: 17.367

4. H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition.

Authors: Patrice Nancy; Johan Siewiera; Gabrielle Rizzuto; Elisa Tagliani; Ivan Osokine; Priyanka Manandhar; Igor Dolgalev; Caterina Clementi; Aristotelis Tsirigos; Adrian Erlebacher
Journal: J Clin Invest Date: 2017-11-27 Impact factor: 14.808

5. βIV-Spectrin/STAT3 complex regulates fibroblast phenotype, fibrosis, and cardiac function.

Authors: Nehal J Patel; Drew M Nassal; Amara D Greer-Short; Sathya D Unudurthi; Benjamin W Scandling; Daniel Gratz; Xianyao Xu; Anuradha Kalyanasundaram; Vadim V Fedorov; Federica Accornero; Peter J Mohler; Keith J Gooch; Thomas J Hund
Journal: JCI Insight Date: 2019-10-17

6. Mechanoregulation of Myofibroblast Fate and Cardiac Fibrosis.

Authors: Peter Kim; Nick Chu; Jennifer Davis; Deok-Ho Kim
Journal: Adv Biosyst Date: 2017-12-04

7. Correlation between circulating fibrocytes and dermal thickness in limited cutaneous systemic sclerosis patients: a pilot study.

Authors: Barbara Ruaro; Stefano Soldano; Vanessa Smith; Sabrina Paolino; Paola Contini; Paola Montagna; Carmen Pizzorni; Andrea Casabella; Samuele Tardito; Alberto Sulli; Maurizio Cutolo
Journal: Rheumatol Int Date: 2019-05-06 Impact factor: 2.631