Literature DB >> 27166403

Tumor Heterogeneity and Tumor Immunity: A Chicken-and-Egg Problem.

Stefani Spranger1.   

Abstract

The overall mutational burden of a tumor is considered to be a predictive marker for the success of checkpoint blockade therapy. A recent study by McGranahan et al. reframes this notion by showing that clonal expression of neoantigens by tumor cells, rather than overall mutational burden, determines the response to checkpoint blockade therapy.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27166403     DOI： 10.1016/j.it.2016.04.008

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  5 in total

1.  Discovering dominant tumor immune archetypes in a pan-cancer census.

Authors:  Alexis J Combes; Bushra Samad; Jessica Tsui; Nayvin W Chew; Peter Yan; Gabriella C Reeder; Divyashree Kushnoor; Alan Shen; Brittany Davidson; Andrea J Barczak; Michael Adkisson; Austin Edwards; Mohammad Naser; Kevin C Barry; Tristan Courau; Taymour Hammoudi; Rafael J Argüello; Arjun Arkal Rao; Adam B Olshen; Cathy Cai; Jenny Zhan; Katelyn C Davis; Robin K Kelley; Jocelyn S Chapman; Chloe E Atreya; Amar Patel; Adil I Daud; Patrick Ha; Aaron A Diaz; Johannes R Kratz; Eric A Collisson; Gabriela K Fragiadakis; David J Erle; Alexandre Boissonnas; Saurabh Asthana; Vincent Chan; Matthew F Krummel
Journal:  Cell       Date:  2021-12-27       Impact factor: 41.582

Review 2.  Neoantigens Generated by Individual Mutations and Their Role in Cancer Immunity and Immunotherapy.

Authors:  Mirjana Efremova; Francesca Finotello; Dietmar Rieder; Zlatko Trajanoski
Journal:  Front Immunol       Date:  2017-11-28       Impact factor: 7.561

Review 3.  Chemokine Receptors and Exercise to Tackle the Inadequacy of T Cell Homing to the Tumor Site.

Authors:  Manja Idorn; Per Thor Straten
Journal:  Cells       Date:  2018-08-17       Impact factor: 6.600

4.  An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles.

Authors:  Mengyuan Li; Zhilan Zhang; Lin Li; Xiaosheng Wang
Journal:  Commun Biol       Date:  2020-09-11

5.  UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma.

Authors:  Yochai Wolf; Osnat Bartok; Sushant Patkar; Gitit Bar Eli; Sapir Cohen; Kevin Litchfield; Ronen Levy; Alejandro Jiménez-Sánchez; Sophie Trabish; Joo Sang Lee; Hiren Karathia; Eilon Barnea; Chi-Ping Day; Einat Cinnamon; Ilan Stein; Adam Solomon; Lital Bitton; Eva Pérez-Guijarro; Tania Dubovik; Shai S Shen-Orr; Martin L Miller; Glenn Merlino; Yishai Levin; Eli Pikarsky; Lea Eisenbach; Arie Admon; Charles Swanton; Eytan Ruppin; Yardena Samuels
Journal:  Cell       Date:  2019-09-12       Impact factor: 41.582
  5 in total

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