Literature DB >> 27165747

A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.

Hui Jing, Jing Hu, Bin He, Yashira L Negrón Abril, Jack Stupinski, Keren Weiser, Marisa Carbonaro, Ying-Ling Chiang, Teresa Southard, Paraskevi Giannakakou, Robert S Weiss, Hening Lin.   

Abstract

Entities:  

Year:  2016        PMID： 27165747     DOI： 10.1016/j.ccell.2016.04.005

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


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  20 in total

1.  Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer.

Authors:  Wenjing Ma; Xiaoping Zhao; Kaiying Wang; Jianjun Liu; Gang Huang
Journal:  Cancer Biol Ther       Date:  2018-08-01       Impact factor: 4.742

2.  A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation.

Authors:  Nicole A Spiegelman; Jun Young Hong; Jing Hu; Hui Jing; Miao Wang; Ian R Price; Ji Cao; Min Yang; Xiaoyu Zhang; Hening Lin
Journal:  ChemMedChem       Date:  2019-02-25       Impact factor: 3.466

3.  Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.

Authors:  Meng Li; Ying-Ling Chiang; Costas A Lyssiotis; Matthew R Teater; Jun Young Hong; Hao Shen; Ling Wang; Jing Hu; Hui Jing; Zhengming Chen; Neeraj Jain; Cihangir Duy; Sucharita J Mistry; Leandro Cerchietti; Justin R Cross; Lewis C Cantley; Michael R Green; Hening Lin; Ari M Melnick
Journal:  Cancer Cell       Date:  2019-06-10       Impact factor: 31.743

4.  Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure.

Authors:  Yi Wang; Yi Man Eva Fung; Weizhe Zhang; Bin He; Matthew Wai Heng Chung; Jing Jin; Jing Hu; Hening Lin; Quan Hao
Journal:  Cell Chem Biol       Date:  2017-03-09       Impact factor: 8.116

5.  EBP50 suppresses the proliferation of MCF-7 human breast cancer cells via promoting Beclin-1/p62-mediated lysosomal degradation of c-Myc.

Authors:  Hong Liu; Wu-Li Zhao; Jia-Ping Wang; Bing-Mu Xin; Rong-Guang Shao
Journal:  Acta Pharmacol Sin       Date:  2017-12-28       Impact factor: 6.150

6.  Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities.

Authors:  Nicole A Spiegelman; Ian R Price; Hui Jing; Miao Wang; Min Yang; Ji Cao; Jun Young Hong; Xiaoyu Zhang; Pornpun Aramsangtienchai; Sushabhan Sadhukhan; Hening Lin
Journal:  ChemMedChem       Date:  2018-08-13       Impact factor: 3.466

Review 7.  Updates on the epigenetic roles of sirtuins.

Authors:  Tatsiana Kosciuk; Miao Wang; Jun Young Hong; Hening Lin
Journal:  Curr Opin Chem Biol       Date:  2019-03-12       Impact factor: 8.822

8.  SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration.

Authors:  Nicole A Spiegelman; Xiaoyu Zhang; Hui Jing; Ji Cao; Ilana B Kotliar; Pornpun Aramsangtienchai; Miao Wang; Zhen Tong; Kelly M Rosch; Hening Lin
Journal:  ACS Chem Biol       Date:  2019-09-03       Impact factor: 5.100

9.  Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells.

Authors:  Imene Hamaidi; Lin Zhang; Nayoung Kim; Min-Hsuan Wang; Cristina Iclozan; Bin Fang; Min Liu; John M Koomen; Anders E Berglund; Sean J Yoder; Jiqiang Yao; Robert W Engelman; Ben C Creelan; Jose R Conejo-Garcia; Scott J Antonia; James J Mulé; Sungjune Kim
Journal:  Cell Metab       Date:  2020-08-07       Impact factor: 27.287

10.  A Set of Highly Sensitive Sirtuin Fluorescence Probes for Screening Small-Molecular Sirtuin Defatty-Acylase Inhibitors.

Authors:  Yuya Nakajima; Mitsuyasu Kawaguchi; Naoya Ieda; Hidehiko Nakagawa
Journal:  ACS Med Chem Lett       Date:  2021-03-11       Impact factor: 4.345
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