Cristiano Spada1, Shabana F Pasha2, Seth A Gross3, Jonathan A Leighton2, Felice Schnoll-Sussman4, Loredana Correale5, Begoña González Suárez6, Guido Costamagna7, Cesare Hassan8. 1. Digestive Endoscopy Unit, Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy. Electronic address: cristianospada@gmail.com. 2. Division of Gastroenterology, Mayo Clinic School of Medicine, Scottsdale, Arizona. 3. Department of Gastroenterology, Tisch Hospital, NYU Langone Medical Center, New York, New York. 4. Department of Gastroenterology, Weill Medical College of Cornell University, New York, New York. 5. Centro Prevenzione Oncologica (CPO)-Piemonte, Turin, Italy. 6. Gastroenterology - ICMDiM, Hospital Clinic de Barcelona, Barcelona, Spain. 7. Digestive Endoscopy Unit, Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy. 8. Digestive Endoscopy Unit, Fondazione Policlinico Universitario "A. Gemelli", Rome, Italy; Department of Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
Abstract
BACKGROUND & AIMS: Colon capsule endoscopy (CCE) is a noninvasive technique used to explore the colon without sedation or air insufflation. A second-generation capsule was recently developed to improve accuracy of detection, and clinical use has expanded globally. We performed a systematic review and meta-analysis to assess the accuracy of CCE in detecting colorectal polyps. METHODS: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and other databases from 1966 through 2015 for studies that compared accuracy of colonoscopy with histologic evaluation with CCE. The risk of bias within each study was ascertained according to Quality Assessment of Diagnostic Accuracy in Systematic Reviews recommendations. Per-patient accuracy values were calculated for polyps, overall and for first-generation (CCE-1) and second-generation (CCE-2) capsules. We analyzed data by using forest plots, the I2 statistic to calculate heterogeneity, and meta-regression analyses. RESULTS: Fourteen studies provided data from 2420 patients (1128 for CCE-1 and 1292 for CCE-2). CCE-2 and CCE-1 detected polyps >6 mm with 86% sensitivity (95% confidence interval [CI], 82%-89%) and 58% sensitivity (95% CI, 44%-70%), respectively, and 88.1% specificity (95% CI, 74.2%-95.0%) and 85.7% specificity (95% CI, 80.2%-90.0%), respectively. CCE-2 and CCE-1 detected polyps >10 mm with 87% sensitivity (95% CI, 81%-91%) and 54% sensitivity (95% CI, 29%-77%), respectively, and 95.3% specificity (95% CI, 91.5%-97.5%) and 97.4% specificity (95% CI, 96.0%-98.3%), respectively. CCE-2 identified all 11 invasive cancers detected by colonoscopy. CONCLUSIONS: The sensitivity in detection of polyps >6 mm and >10 mm increased substantially between development of first-generation and second-generation colon capsules. High specificity values for detection of polyps by CCE-2 seem to be achievable with a 10-mm cutoff and in a screening setting.
BACKGROUND & AIMS: Colon capsule endoscopy (CCE) is a noninvasive technique used to explore the colon without sedation or air insufflation. A second-generation capsule was recently developed to improve accuracy of detection, and clinical use has expanded globally. We performed a systematic review and meta-analysis to assess the accuracy of CCE in detecting colorectal polyps. METHODS: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and other databases from 1966 through 2015 for studies that compared accuracy of colonoscopy with histologic evaluation with CCE. The risk of bias within each study was ascertained according to Quality Assessment of Diagnostic Accuracy in Systematic Reviews recommendations. Per-patient accuracy values were calculated for polyps, overall and for first-generation (CCE-1) and second-generation (CCE-2) capsules. We analyzed data by using forest plots, the I2 statistic to calculate heterogeneity, and meta-regression analyses. RESULTS: Fourteen studies provided data from 2420 patients (1128 for CCE-1 and 1292 for CCE-2). CCE-2 and CCE-1 detected polyps >6 mm with 86% sensitivity (95% confidence interval [CI], 82%-89%) and 58% sensitivity (95% CI, 44%-70%), respectively, and 88.1% specificity (95% CI, 74.2%-95.0%) and 85.7% specificity (95% CI, 80.2%-90.0%), respectively. CCE-2 and CCE-1 detected polyps >10 mm with 87% sensitivity (95% CI, 81%-91%) and 54% sensitivity (95% CI, 29%-77%), respectively, and 95.3% specificity (95% CI, 91.5%-97.5%) and 97.4% specificity (95% CI, 96.0%-98.3%), respectively. CCE-2 identified all 11 invasive cancers detected by colonoscopy. CONCLUSIONS: The sensitivity in detection of polyps >6 mm and >10 mm increased substantially between development of first-generation and second-generation colon capsules. High specificity values for detection of polyps by CCE-2 seem to be achievable with a 10-mm cutoff and in a screening setting.
Authors: David Kastenberg; Wilmot C Burch; David P Romeo; Pankaj K Kashyap; David C Pound; Neophytos Papageorgiou; Ignacio Fernández-Urien Sainz; Carly E Sokach; Douglas K Rex Journal: World J Gastroenterol Date: 2017-12-28 Impact factor: 5.742
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Authors: Gerard Cummins; Benjamin F Cox; Gastone Ciuti; Thineskrishna Anbarasan; Marc P Y Desmulliez; Sandy Cochran; Robert Steele; John N Plevris; Anastasios Koulaouzidis Journal: Nat Rev Gastroenterol Hepatol Date: 2019-07 Impact factor: 46.802