Literature DB >> 27165330

Microalgae as Solar-Powered Protein Factories.

Franziska Hempel1, Uwe G Maier2,3.   

Abstract

Microalgae have an enormous ecological relevance as they contribute significantly to global carbon fixation. But also for biotechnology microalgae became increasingly interesting during the last decades as many algae provide valuable natural products. Especially the high lipid content of some species currently attracts much attention in the biodiesel industry. A further application that emerged some years ago is the use of microalgae as expression platform for recombinant proteins. Several projects on the production of therapeutics, vaccines and feed supplements demonstrated the great potential of using microalgae as novel low-cost expression platform. This review provides an overview on the prospects and advantages of microalgal protein expression systems and gives an outlook on potential future applications.

Entities:  

Keywords:  Bioreactor; Microalgae; Protein expression platform; Recombinant proteins

Mesh:

Substances:

Year:  2016        PMID: 27165330     DOI: 10.1007/978-3-319-27216-0_16

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  11 in total

Review 1.  Manipulation of the microalgal chloroplast by genetic engineering for biotechnological utilization as a green biofactory.

Authors:  Yong Min Kwon; Kyung Woo Kim; Tae-Young Choi; Sun Young Kim; Jaoon Young Hwan Kim
Journal:  World J Microbiol Biotechnol       Date:  2018-11-26       Impact factor: 3.312

2.  Recombinant Protein Production and Purification of Insoluble Proteins.

Authors:  Neus Ferrer-Miralles; Paolo Saccardo; José Luis Corchero; Elena Garcia-Fruitós
Journal:  Methods Mol Biol       Date:  2022

Review 3.  Microalgal Cell Biofactory-Therapeutic, Nutraceutical and Functional Food Applications.

Authors:  Boda Ravi Kiran; S Venkata Mohan
Journal:  Plants (Basel)       Date:  2021-04-21

4.  From hybridomas to a robust microalgal-based production platform: molecular design of a diatom secreting monoclonal antibodies directed against the Marburg virus nucleoprotein.

Authors:  Franziska Hempel; Michael Maurer; Björn Brockmann; Christian Mayer; Nadine Biedenkopf; Anne Kelterbaum; Stephan Becker; Uwe G Maier
Journal:  Microb Cell Fact       Date:  2017-07-27       Impact factor: 5.328

5.  Multigenic engineering of the chloroplast genome in the green alga Chlamydomonas reinhardtii.

Authors:  Marco Larrea-Alvarez; Saul Purton
Journal:  Microbiology (Reading)       Date:  2020-06       Impact factor: 2.777

6.  Using a marine microalga as a chassis for polyethylene terephthalate (PET) degradation.

Authors:  Daniel Moog; Johanna Schmitt; Jana Senger; Jan Zarzycki; Karl-Heinz Rexer; Uwe Linne; Tobias Erb; Uwe G Maier
Journal:  Microb Cell Fact       Date:  2019-10-10       Impact factor: 5.328

7.  Comparative Structural and Functional Analyses of the Fusiform, Oval, and Triradiate Morphotypes of Phaeodactylum tricornutum Pt3 Strain.

Authors:  Ludovic Galas; Carole Burel; Damien Schapman; Marc Ropitaux; Sophie Bernard; Magalie Bénard; Muriel Bardor
Journal:  Front Plant Sci       Date:  2021-04-12       Impact factor: 5.753

Review 8.  Green biologics: The algal chloroplast as a platform for making biopharmaceuticals.

Authors:  Henry N Taunt; Laura Stoffels; Saul Purton
Journal:  Bioengineered       Date:  2017-09-29       Impact factor: 3.269

9.  Downstream Processing of Chlamydomonas reinhardtii TN72 for Recombinant Protein Recovery.

Authors:  Laura Stoffels; Arran Finlan; Gareth Mannall; Saul Purton; Brenda Parker
Journal:  Front Bioeng Biotechnol       Date:  2019-12-06

Review 10.  Recent Advancements and Future Perspectives of Microalgae-Derived Pharmaceuticals.

Authors:  Donghua Xia; Wen Qiu; Xianxian Wang; Junying Liu
Journal:  Mar Drugs       Date:  2021-12-12       Impact factor: 5.118

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