Literature DB >> 27163767

Successful Curative Therapy With Rituximab and Allogeneic Haematopoietic Stem Cell Transplantation for MALT Lymphoma Associated With STK4-Mutated CD4+ Lymphocytopenia.

Su Han Lum1, Denise Bonney1, Edmund Cheesman2, Neville B Wrignt3, Stephen Hughes4, Robert Wynn1.   

Abstract

Idiopathic CD4+ lymphocytopenia and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are rare diseases in children. We report the first case of a child with STK4-mutated CD4+ lymphocytopenia who developed Epstein-Barr virus associated MALT lymphoma arising in the salivary gland. The child achieved complete remission with rituximab, and her immunodeficiency was cured by haematopoietic stem cell transplantation. The child remained well 24 months post transplantation.
© 2016 Wiley Periodicals, Inc.

Entities:  

Keywords:  CD4+ lymphocytopenia; MALT lymphoma; haematopoietic stem cell transplantation; rituximab

Mesh：

Substances：

Year:  2016        PMID： 27163767     DOI： 10.1002/pbc.26048

Source DB:  PubMed          Journal:  Pediatr Blood Cancer        ISSN： 1545-5009            Impact factor:   3.167


  4 in total

1.  Genomic landscape of Epstein-Barr virus-positive extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue.

Authors:  Bryan Rea; Yen-Chun Liu; Alanna Maguire; Lorinda A Soma; Chris M Bacon; Michael G Bayerl; Molly H Smith; Michael T Barrett; Steven H Swerdlow; Sarah E Gibson
Journal:  Mod Pathol       Date:  2021-12-24       Impact factor: 8.209

Review 2.  Hematopoietic Stem Cell Transplantation in Primary Immunodeficiency Diseases: Current Status and Future Perspectives.

Authors:  Riccardo Castagnoli; Ottavia Maria Delmonte; Enrica Calzoni; Luigi Daniele Notarangelo
Journal:  Front Pediatr       Date:  2019-08-08       Impact factor: 3.418

Review 3.  Idiopathic CD4 Lymphocytopenia: Current Insights.

Authors:  Saravanakumari Vijayakumar; Stalin Viswanathan; Rajeswari Aghoram
Journal:  Immunotargets Ther       Date:  2020-05-14

4.  A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes.

Authors:  Andrea Guennoun; Salim Bougarn; Taushif Khan; Rafah Mackeh; Mahbuba Rahman; Fatima Al-Ali; Manar Ata; Waleed Aamer; Debra Prosser; Tanwir Habib; Evonne Chin-Smith; Khawla Al-Darwish; Qian Zhang; Alya Al-Shakaki; Amal Robay; Ronald G Crystal; Khalid Fakhro; Amal Al-Naimi; Eman Al Maslamani; Amjad Tuffaha; Ibrahim Janahi; Mohammad Janahi; Donald R Love; Mohammed Yousuf Karim; Bernice Lo; Amel Hassan; Mehdi Adeli; Nico Marr
Journal:  J Clin Immunol       Date:  2021-08-24       Impact factor: 8.317
  4 in total

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